International Journal of Clinical Case Reports 2024, Vol.14, No.1, 31-39 http://medscipublisher.com/index.php/ijccr 35 Shi et al. (2017) found that a healthy intestinal microbiome promotes intestinal health through interaction with the intestinal immune system, while microbiome imbalance (Dysbiosis) may lead to the occurrence of intestinal diseases. Furthermore, the impact of the gut microbiome on the integrity of the intestinal mucosal barrier and its long-term impact on intestinal health are discussed. After reviewing many documents, Lee et al. (2022) explained how a high-fat diet disrupts intestinal oxygen control and nitrate exposure, leading to changes in the intestinal microbiome, and discussed intervening in the intestinal microbiome by regulating host intestinal physiology. Potential pathways for imbalance. The gut microbiome is critical for maintaining the integrity and function of the intestinal barrier. The intestinal barrier prevents harmful substances and pathogens from entering the intestines and protects intestinal health. 3 Research Situation 3.1 Intestinal microbiome and intestinal inflammatory diseases In recent years, the relationship between the gut microbiome and intestinal inflammatory diseases has attracted widespread attention. Research shows that dysbiosis of the gut microbiome plays an important role in the pathogenesis of inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis. The number of beneficial bacteria in the patient's intestines decreases, while harmful bacteria increase, leading to an imbalance in the intestinal environment. Certain gut bacteria can trigger abnormal immune responses, further exacerbating intestinal inflammation. Curtis Huttenhower, a member of the HMP2 project and the leader of this study, Professor of Computational Biology and Bioinformatics at Harvard University, and his colleagues followed 132 participants for a year , conducted multi-dimensional molecular profiling analysis of the samples, and observed for the first time A complex series of chemical and molecular events (Lloyd-Price et al., 2019). They can disrupt the microbiota during the pathogenesis of IBD and trigger immune responses, and biochemical differences in IBD patients during dysbiosis, such as dramatic changes in acylcarnitine levels (Figure 2). Figure 2 The microbiome changes are more frequent and extreme in IBD patients (Lloyd-Price et al., 2019) 3.2 Intestinal microbiome and intestinal metabolic diseases There is also a close connection between the intestinal microbiome and intestinal metabolic diseases. Studies have shown that imbalance of the intestinal microbiome may lead to the occurrence of metabolic diseases such as obesity and diabetes (Gu et al., 2019). Certain intestinal bacteria can promote the absorption and storage of fat, leading to obesity. The gut microbiome can also influence the host's absorption and utilization of glucose, thereby affecting blood sugar levels.
RkJQdWJsaXNoZXIy MjQ4ODYzNQ==