International Journal of Clinical Case Reports 2024, Vol.14, No.1, 31-39 http://medscipublisher.com/index.php/ijccr 31 Review and Progress Open Access The Impact of the Human Microbiome on Gut Health: Recent Research Shunyi Chen Institute of Life Science, Jiyang College of Zhejiang A&F University, Zhuji, 311800, Zhejiang, China Corresponding author email: ssoy1@outlook.com International Journal of Clinical Case Reports 2024, Vol.14, No.1 doi: 10.5376/ijccr.2024.14.0004 Received: 02 Feb., 2024 Accepted: 09 Mar., 2024 Published: 29 Mar., 2024 Copyright © 2024 Chen, This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Preferred citation for this article: Chen S.Y., 2024, The impact of the human microbiome on gut health: recent research, International Journal of Clinical Case Reports, 14(1): 31-39 (doi: 10.5376/ijccr.2024.14.0004) Abstract In this study, the composition and diversity of the intestinal microbiome and its interaction with the host are discussed in depth, and the key role of the microbiome in maintaining intestinal balance, promoting nutrient absorption, and preventing and treating intestinal diseases is revealed. It also introduces the current hot areas of microbiome research, including the relationship between microbiome and chronic diseases, drug response, and the development and application prospects of microbiome regulation methods. These findings provide an important basis for further understanding of the physiological functions and regulatory mechanisms of the gut microbiome, as well as the development of microbiome based intestinal health intervention strategies. Keywords Body microbiome; Intestinal health; Intestinal microbial balance; Intestinal disease In recent years, with the development of high-throughput sequencing technology and the advancement of bioinformatics methods, the study of human microbiome has become a research hotspot in the field of life sciences. The human microbiome is not only closely related to human health, but also plays an important role in the occurrence and development of diseases. Therefore, in-depth exploration of the impact of the human microbiome on intestinal health is of great significance for understanding the nature of human health and disease, and for developing new disease diagnosis and treatment strategies (Hills et al., 2019). The importance of the human microbiome is reflected in the fact that the human microbiome plays an important role in maintaining normal physiological functions of the human body, such as promoting the digestion and absorption of nutrients and participating in the synthesis of vitamins (Conlon and Bird, 2014); the human microbiome interacts with the human immune system to jointly resist the invasion of foreign pathogens; the imbalance of the human microbiome is closely related to the occurrence and development of various diseases, such as intestinal inflammation, metabolic diseases, and autoimmunity Diseases, etc. In-depth study of the human microbiome is important for understanding the nature of human health and disease. The intestine is the largest microbial habitat in the human body, and the intestinal microbiome is an important component of the human microbiome. The relationship between the gut microbiome and gut health is close and complex (Bäumler and Sperandio, 2016). On the one hand, the intestinal microbiome promotes intestinal health by participating in the digestion and absorption of nutrients, synthesizing vitamins, secreting short-chain fatty acids, etc.; on the other hand, the intestinal microbiome interacts with the intestinal immune system to jointly resist foreign pathogens invasion and maintain intestinal homeostasis. The imbalance of the intestinal microbiome is closely related to the occurrence and development of various intestinal diseases, such as inflammatory bowel disease, irritable bowel syndrome, colon cancer, etc. In-depth exploration of the relationship between the intestinal microbiome and intestinal health is of great significance for understanding the pathogenesis of intestinal diseases and developing novel disease diagnosis and treatment strategies. This study aims to deeply explore the impact and mechanism of the human microbiome on intestinal health. By analyzing the composition, structure, function and interaction between the intestinal microbiome and the
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