Cancer Genetics and Epigenetics, 2025, Vol.13, No.6, 254-264 http://medscipublisher.com/index.php/cge 254 Systematic Review Open Access The Impact of Multidisciplinary Team (MDT) Model on the Prognosis of Patients with Malignant Tumors Yong Cheng Physicov Med. Tech. Ltd., Zhuji, 311800, Zhejiang, China Corresponding email: 2741098603@qq.com Cancer Genetics and Epigenetics, 2025, Vol.13, No.6 doi: 10.5376/cge.2025.13.0026 Received: 20 Aug., 2025 Accepted: 22 Sep., 2025 Published: 10 Nov., 2025 Copyright © 2025 Cheng, This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Preferred citation for this article: Cheng Y., 2025, The impact of multidisciplinary team (MDT) model on the prognosis of patients with malignant tumors, Cancer Genetics and Epigenetics, 13(6): 254-264 (doi: 10.5376/cge.2025.13.0026) Abstract This study discusses the role of the MDT model in improving patients' survival rate, quality of life, degree of treatment cooperation and satisfaction. A large number of studies on diseases such as breast cancer, lung cancer, colorectal cancer and gastric cancer have found that the application of this model can significantly prolong the overall survival and progression-free survival of patients, help doctors more standardize the implementation of clinical diagnosis and treatment guidelines, and also enable patients to enter the treatment stage earlier. While enhancing the therapeutic effect, MDT can also alleviate patients' psychological pressure and promote more patient-centered holistic care. This article also summarizes some key links that affect the effectiveness of MDT, such as collaboration among teams, support from hospital management, and timely information sharing, and points out that there are still problems such as insufficient resources and inconsistent evaluation standards at present. In the future, the development of the MDT model will place greater emphasis on digital construction, the application of artificial intelligence, and the active participation of patients, thereby further enhancing the team's work efficiency. Nowadays, the MDT model has become an important foundation for achieving precise and high-quality cancer treatment, bringing tangible benefits to both patients and the medical system. Keywords Multidisciplinary team (MDT); Malignant tumors; Patient prognosis; Survival outcomes; Quality of life 1 Introduction Cancer is a prominent public health issue worldwide. Data from 2022 indicates that there are approximately 20 million new cancer cases and about 9.7 million deaths from cancer worldwide each year. The incidence and mortality rates vary greatly among different countries and regions. Among them, lung cancer, breast cancer, colorectal cancer, prostate cancer and stomach cancer are the most common. Lung cancer remains the leading cause of cancer-related deaths to this day, with approximately 1.8 million people dying from it each year (Cheng et al., 2016; Bray et al., 2018; Sung et al., 2021). Due to the influence of population aging and multiple factors such as smoking, obesity and infection, it is estimated that by 2050, the number of new cancer cases worldwide will increase to approximately 35 million each year. Especially in developing countries, the burden of cancer may rise at a faster rate, which further highlights the importance of taking effective preventive and therapeutic measures as early as possible (Zhang et al., 2023; Bray et al., 2024). In the past, cancer treatment was often handled by a single department or doctor, and this approach had many problems. The specific manifestations are that the treatment process is not continuous, the time for seeing a doctor and receiving treatment is prolonged, and the treatment standards are not uniform, resulting in poor recovery effects for patients. The treatment approach of a single discipline is difficult to deal with the complex situation of cancer-cancer often requires the simultaneous use of multiple treatment methods, and its multi-faceted impact on the patient's physical, psychological and social life also needs to be considered (Berardi et al., 2020; Popat et al., 2020). The traditional treatment mode is also prone to problems such as repetitive treatment, contradictory regimens, poor coordination among various links, and incomplete assistance to patients, which will ultimately affect the survival time and quality of life of patients (Taberna et al., 2020; Thenuwara et al., 2023; Liu et al., 2024).
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