Cancer Genetics and Epigenetics, 2025, Vol.13, No.5, 224-235 http://medscipublisher.com/index.php/cge 231 7 Comprehensive Mixed Intervention Model 7.1 The combination of mobile applications and remote monitoring When used in conjunction with remote monitoring, mobile medical apps can not only record symptoms at any time but also provide patients with more support in various aspects. Research shows that remote monitoring combined with electronic patient reporting (ePs) can significantly improve the quality of life of cancer patients, alleviate physical discomfort, and enhance their self-management ability. This is particularly evident in patients who have undergone surgery or are undergoing treatment (Coltman et al., 2023; Morelle et al., 2024). This combination approach can continuously obtain information, provide real-time feedback and personalized suggestions, help patients deal with symptoms more proactively, and also facilitate the medical team to detect abnormalities early and adjust treatment in a timely manner (He et al., 2024; Tian et al., 2025). In addition, remote monitoring platforms are usually equipped with functions such as automatic reminders, online doctor contact, and electronic medical record integration, which help make the nursing process more convenient and reduce the need for emergency and hospitalization. Monitoring outside the hospital can not only improve patient satisfaction and sense of participation, but also contribute to more rational utilization of oncology medical resources (Pierce et al., 2024). 7.2 Utilize digital platforms to carry out multi-disciplinary team collaboration Digital health interventions are increasingly being integrated into multidisciplinary team collaborations, with team members including oncologists, nurses, and psychological experts, among others. Digital platforms can share patients' feedback, symptoms and treatment progress, assist teams in collaboration and achieve patient-centered care (Ancona et al., 2025). For instance, the CAPRI trial found that combining nurse-led remote monitoring with a platform system used by patients could enhance patient participation in treatment, reduce side effects, and improve the treatment experience of patients taking oral anti-cancer drugs. With the support of digital platforms, the team can respond promptly based on real-time information, adjust the care plan, and provide more comprehensive support covering physical, psychological and social aspects. This comprehensive intervention approach has been proven to improve the treatment outcomes of patients, enhance their quality of life and satisfaction, and also demonstrates the significance of digital means in the treatment of complex cancers. 7.3 Combination of manual support and automatic intervention Although automated interventions (such as symptom alerts, health education modules and self-management tools) are convenient and efficient, to truly help patients, human support is still indispensable. Research has found that compared with relying solely on automated systems, combining automated tools with manual guidance, such as remote counseling, nurse follow-ups or real-time doctor consultations, can better improve patients' quality of life and psychological state. Artificial support can also enhance patients' participation, offer emotional care, and provide more appropriate solutions to complex or urgent problems. The combined use of manual and automatic methods can adapt to the needs and habits of different patients, allowing technology to truly assist medical care rather than replace direct communication between doctors and patients. Such an approach can make patients more willing to use digital intervention methods and more cooperative with treatment, thereby continuously improving their health levels. 8 Challenges and Future Directions 8.1 Main challenges Although digital health interventions based on applications and remote monitoring show good potential, whether patients can stick to using them remains an important question. As time goes by, the frequency with which users utilize digital tools often gradually decreases. Continuous use is influenced by factors such as the user's motivation, perceived benefits, and whether the tool is easy to operate. Furthermore, digital usage differences - that is, the gaps in the use of smartphones, Internet access and digital skills-may limit the popularization and fairness of such interventions, especially having a greater impact on the elderly, rural areas or people with poorer economic conditions (Ramlee and Satar, 2024).
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