Cancer Genetics and Epigenetics, 2025, Vol.13, No.5, 215-223 http://medscipublisher.com/index.php/cge 215 Systematic Review Open Access Comparison and Optimization Pathways of End-of-Life Care Nursing Models for Advanced Cancer Patients JieWang Zhuji People’s Hospital, Zhuji, 311800, Zhejing, China Corresponding email: 2308763906@qq.com Cancer Genetics and Epigenetics, 2025, Vol.13, No.5 doi: 10.5376/cge.2025.13.0022 Received: 13 Jul., 2025 Accepted: 18 Aug., 2025 Published: 30 Sep., 2025 Copyright © 2025 Wang, This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Preferred citation for this article: Wang J., 2025, Comparison and optimization pathways of end-of-life care nursing models for advanced cancer patients, Cancer Genetics and Epigenetics, 13(5): 215-223 (doi: 10.5376/cge.2025.13.0022) Abstract This study explores several hospice care approaches for patients with advanced cancer, including hospital/hospice ward care, home and community care, as well as multidisciplinary team collaboration models. Research has found that the care methods in hospitals and hospice wards can enable patients to quickly access medical resources and effectively control symptoms, but they may lead to problems such as over-treatment and insufficient personalized care. Family and community care can enable patients to receive care in a familiar environment and achieve a "good death", but it is often affected by insufficient resources and inadequate support from caregivers. The multidisciplinary and nurse-led model is significantly more effective in alleviating symptoms, maintaining mental health, and enhancing family satisfaction. The article also points out the current problems existing in hospice care, such as lack of resources, insufficient policy support, inadequate professional capabilities, and cultural obstacles. To optimize end-of-life care in the future, it is necessary to enhance policy and insurance support, promote the integration of medical care and nursing as well as multi-disciplinary cooperation, improve the professional training system, and raise public awareness of end-of-life care. Only in this way can patient-centered, comprehensive and high-quality end-of-life care services be achieved. Keywords End-of-life care; Advanced cancer patients; Nursing models; Multidisciplinary collaboration; Optimization pathways 1 Introduction The number of patients with advanced cancer worldwide has been increasing, especially among the elderly. It is predicted that in the coming years, up to 70% of cancer patients may occur in people aged 65 and above. As the survival conditions of many patients with advanced cancer have not changed much, people have begun to pay more attention to improving the quality of life and ensuring that patients can complete their last days with dignity and comfort. EoL care is of great significance in meeting the complex physical, psychological, social and spiritual needs of patients and their families. Its aim is to offer comfort, alleviate symptoms and provide assistance to patients in their final stages of life (Ghezelsefli et al., 2020). Recent research indicates that nurses and multidisciplinary teams play a crucial role in providing effective EoL care to patients with advanced cancer. From nurse-led multidisciplinary hospice care to more advanced nursing interventions, various nursing models have been proven to improve the quality of life of patients, enhance emotional health, and make patients more satisfied with nursing (Liu et al., 2024; Useck-Guerrero et al., 2024). A comprehensive care approach that combines psychological, spiritual and educational support is increasingly regarded as a good practice. It has also been proven that integrating palliative care with advance care planning earlier can reduce excessive treatment intervention and make care in line with the patient's wishes (Lin et al., 2018; Hua et al., 2024). However, problems still exist, such as the inconsistent definition of EoL, different nursing models, and deficiencies in nurse education and support (Crawford et al., 2021;Terzi and Kapucu, 2022; Jeong et al., 2023). This study will comparatively analyze the existing EoL care models for patients with advanced cancer, assess the effectiveness of these models, and identify optimization directions for future care practices. This study aims to introduce the current nursing models and their effects, analyze multidisciplinary and nurse-led nursing interventions, discuss the difficulties encountered in doing EoL nursing well and the factors that can be helpful,
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