CGE2025v13n2

1 Introduction	31
2 Review of Histone Modification	32
2.1 Structure and function of histones and chromat	32
Histones are the core proteins that compress DNA a	32
Chromatin is not fixed but a flexible structure th	32
2.2 Histone modification types	32
Histone modification is a chemical alteration (PTM	32
Acetylation mainly occurs on lysine and is usually	32
2.3 The general role of histone modification in ge	32
Histone modification plays a core role in controll	32
In cancer, the imbalance of histone modification i	33
3 The role of Histone Methylation in Prostate Canc	33
3.1 Histone methylation mechanisms: H3K4, H3K9, H3	33
Histone methylation is a key epigenetic change tha	33
H3K27 methylation catalyzed by the multi-comb inhi	33
3.2 Dysmethylation in prostate cancer: its role in	34
The imbalance of histone methylation is an importa	34
The mutual influence among different histone marke	34
3.3 Therapeutic significance: targeting methyltran	34
Targeting histone methyltransferases and demethyla	34
Targeting NSD2 and other H3K36 methyltransferases	34
4 The Role of Histone Acetylation in Prostate Canc	34
4.1 The role of acetylation in chromatin structure	34
Histone acetylation is an important chemical modif	34
Li et al. (2020) found that acetylation and deacet	34
4.2 Histone acetyltransferases and histone deacety	34
During the occurrence and development of prostate	34
4.3 Therapeutic potential of HDAC inhibitors	35
HDAC inhibitors (HDACi) have brought new hope for	35
5 Crosstalk of Five Histone Modifications in Prost	36
5.1 Synergistic effects among different histone mo	36
Histone modifications do not function alone; there	36
There is a mutual inhibitory relationship between	36
5.2 Chromatin remodeling and transcriptional regul	36
The changes in chromatin structure are an importan	36
When histone variants like H3.3 bind to chromatin,	36
5.3 Role in the invasion and progression of prosta	36
The interaction among histone modifications is not	36
6 Histone Modification and Drug Resistance in Pros	37
6.1 The role of histone modification in the occurr	37
Histone modification has a significant impact on a	37
Imamura et al. (2023) found that prostate cancer c	37
6.2 Epigenetic reprogramming leading to drug resis	38
Epigenetic reprogramming, including histone modifi	38
6.3 Clinical significance of histone modification	38
Histone modification has a high clinical value in	38
7 Emerging Treatment Methods for Histone Modificat	38
7.1 Development of epigenetic drugs: HDAC and meth	38
The development of epigenetic drugs is very promis	38
7.2 Combination therapy for histone modification a	38
Combining epigenetic drugs with traditional cancer	38
7.3 Clinical outcomes and challenges of prostate c	38
8 Challenges and Future Directions	39
8.1 Challenges in translating epigenetic findings	39
There are many difficulties in applying the resear	39
8.2 Personalized medical potential based on histon	39
Despite these challenges, histone modification sti	39
8.3 Future research directions: new biomarkers and	39
9 Concluding Remarks	40

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