Cancer Genetics and Epigenetics, 2025, Vol.13, No.1, 11-20 http://medscipublisher.com/index.php/cge 11 Research Insight Open Access Anti-inflammatory Diets in Pancreatic Cancer Management: Mechanisms and Clinical Evidence JianWang Zhuji Tongji Hospital, Zhuji, 311800, Zhejiang, China Corresponding email: 1136425476@qq.com Cancer Genetics and Epigenetics, 2025, Vol.13, No.1 doi: 10.5376/cge.2025.13.0002 Received: 25 Nov., 2024 Accepted: 03 Jan., 2025 Published: 20 Jan., 2025 Copyright © 2025 Wang, This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Preferred citation for this article: Wang J., 2025, Anti-inflammatory diets in pancreatic cancer management: mechanisms and clinical evidence, Cancer Genetics and Epigenetics, 13(1): 11-20 (doi: 10.5376/cge.2025.13.0002) Abstract This study explored the key role of chronic inflammation in the occurrence and development of pancreatic cancer, including the imbalance of immune cells in the surrounding environment of the tumor, and how the activation of signaling pathways such as NF-κB, STAT3 and COX-2 promotes tumor progression. Subsequently, the main anti-inflammatory components-polyphenols (such as curcumin, resveratrol), omega-3 polyunsaturated fatty acids (EPA/DHA), and dietary fiber were introduced emphatically. This article also explores the supportive data from in vitro experiments and animal models, which show the impact of anti-inflammatory diets on tumor growth, inflammatory markers and molecular mechanisms. Epidemiological studies and limited clinical intervention studies have shown that a dietary pattern rich in fruits, vegetables, whole grains and healthy fats is associated with a reduced risk of pancreatic cancer and improved inflammatory indicators. However, most of these studies are observational studies, and large-scale randomized controlled trials are still lacking at present. This study presents practical suggestions for incorporating anti-inflammatory diets into personalized nutritional assessment and comprehensive treatment plans, and Outlines future research directions, including multi-center clinical trials, validation of nutritional biomarkers, and exploration of synergistic effects with immunotherapy. Keywords Anti-inflammatory diet; Pancreatic cancer; Polyphenols; ω-3 polyunsaturated fatty acids; Inflammatory signaling pathways 1 Introduction Pancreatic cancer is regarded as one of the most aggressive and fatal cancers, with poor treatment outcomes and a large number of deaths. Although medical standards have improved, the number of people suffering from pancreatic cancer worldwide is still increasing. Because the discovery was late and there were few effective treatment methods, the proportion of patients who survived was still not high (Afshare et al., 2022; Lee et al., 2024). This disease is often diagnosed only when it becomes very serious, resulting in a low five-year survival rate. Therefore, prevention and early detection have become important goals of public health (Cayssials et al., 2022). Long-term inflammation in the body is a known cause of the occurrence and progression of pancreatic cancer. Internal factors of the body (such as genetic changes that cause cancer) and external factors (such as smoking, obesity, diet and other lifestyles) can both cause a persistent inflammatory state. This state will help the tumor grow, enlarge and evade the body's immunity. Especially diet, it can affect the degree of inflammation throughout the body. A diet that is prone to causing inflammation increases the risk of pancreatic cancer, while a diet that combats inflammation may play a protective role by reducing inflammatory substances and oxidative stress in the body (Shivappa et al., 2015; Cassssials et al., 2022; Chen et al., 2024). An inflamed environment not only promotes the occurrence of cancer, but also leads to ineffective treatment and bad outcomes (Todoric et al., 2016; Hu et al., 2022). This study will analyze how anti-inflammatory diets can help deal with pancreatic cancer, including their mechanism of action and practical effects. Given the crucial role of inflammation in the formation of pancreatic cancer, reducing inflammation through dietary adjustments is a promising, non-surgical preventive and
RkJQdWJsaXNoZXIy MjQ4ODYzNA==