CGE2025v13n1

Cancer Genetics and Epigenetics, 2025, Vol.13, No.1, 1-10 http://medscipublisher.com/index.php/cge 8 Chen Z.S., Guo X.Y., Tao R., Huyghe J.R., Law P., Fernández-Rozadilla C., Ping J., Jia G., Long J., Li C., Shen Q., Xie Y., Timofeeva, M., Thomas M., Schmit S., Díez-Obrero V., Devall M., Moratalla-Navarro F., Fernandez-Tajes J., Palles C., Sherwood K., Briggs S., Svinti V., Donnelly K., Farrington S., Blackmur J., Vaughan-Shaw P., Shu X., Lu Y., Broderick P., Studd J., Harrison T., Conti D., Schumacher F., Melas M., Rennert G., Obón-Santacana M., Martín-Sánchez V., Oh J., Kim J., Jee S., Jung K., Kweon S., Shin M., Shin A., Ahn Y., Kim D., Oze I., Wen W., Matsuo K., Matsuda K., Tanikawa C., Ren Z., Gao Y., Jia W., Hopper J., Jenkins M., Win A., Pai R., Figueiredo J., Haile R., Gallinger S., Woods M., Newcomb P., Duggan D., Cheadle J., Kaplan R., Kerr R., Kerr D., Kirac I., Böhm J., Mecklin J., Jousilahti P., Knekt P., Aaltonen L., Rissanen H., Pukkala E., Eriksson J., Cajuso T., Hänninen U., Kondelin J., Palin K., Tanskanen T., Renkonen-Sinisalo L., Männistö S., Albanes D., Weinstein S., Ruiz-Narvaez E., Palmer J., Buchanan D., Platz E., Visvanathan K., Ulrich C., Siegel E., Brezina S., Gsur A., Campbell P., Chang-Claude J., Hoffmeister M., Brenner H., Slattery M., Potter J., Tsilidis K., Schulze M., Gunter M., Murphy N., Castells A., Castellví-Bel S., Moreira L., Arndt V., Shcherbina A., Bishop D., Giles G., Southey M., Idos G., McDonnell K., Abu-Ful Z., Greenson J., Shulman K., Lejbkowicz F., Offit K., Su Y., Steinfelder R., Keku T., Van Guelpen B., Hudson T., Hampel H., Pearlman R., Berndt S., Hayes R., Martínez M., Thomas S., Pharoah P., Larsson S., Yen Y., Lenz H., White E., Li L., Doheny K., Pugh E., Shelford T., Chan A., Cruz-Correa M., Lindblom A., Hunter D., Joshi A., Schafmayer C., Scacheri P., Kundaje A., Schoen R., Hampe J., Stadler Z., Vodicka P., Vodickova L., Vymetálková V., Edlund C., Gauderman W., Shibata D., Toland A., Markowitz S., Kim A., 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Ulrike P., Zheng W., Casey G., and Guo X.Y., 2023, Novel insights into genetic susceptibility for colorectal cancer from transcriptome-wide association and functional investigation, Journal of the National Cancer Institute, 116(1): 127-137. https://doi.org/10.1093/jnci/djad178 Chubb D., Broderick P., Frampton M., Kinnersley B., Sherborne A., Penegar S., Lloyd, A., Ma Y., Dobbins S., and Houlston R., 2015, Genetic diagnosis of high-penetrance susceptibility for colorectal cancer (CRC) is achievable for a high proportion of familial CRC by exome sequencing, Journal of Clinical Oncology, 33(5): 426-432. https://doi.org/10.1200/JCO.2014.56.5689 Dueñas N., Klinkhammer H., Bonifaci N., Spier I., Mayr A., Hassanin E., Díez-Villanueva A., Moreno V., Pineda M., Maj C., Capellá G., Aretz S., and Brunet J., 2023, Ability of a polygenic risk score to refine colorectal cancer risk in lynch syndrome, Journal of Medical Genetics, 60: 1044-1051. https://doi.org/10.1136/jmg-2023-109344 Frampton M., Law P., Litchfield K., Morris E., Kerr D., Turnbull C., Turnbull C., Tomlinson I., and Houlston R., 2016, Implications of polygenic risk for personalised colorectal cancer screening, Annals of Oncology, 27(3): 429-434. https://doi.org/10.1093/annonc/mdv540 Guo F., Edelmann D., Cardoso R., Chen X., Carr P., Chang-Claude J., Hoffmeister M., and Brenner H., 2022, Polygenic risk score for defining personalized surveillance intervals after adenoma detection and removal at colonoscopy, Clinical Gastroenterology and Hepatology, 21(1): 210-219. https://doi.org/10.1016/j.cgh.2022.03.013 Guo F., Weigl K., Carr P.R., Heisser T., Jansen L., Knebel P., Chang-Claude J., Hoffmeister M., and Brenner H., 2020, Use of polygenic risk scores to select screening intervals after negative findings from colonoscopy, Clinical Gastroenterology and Hepatology, 18(12): 2742-2751. https://doi.org/10.1016/j.cgh.2020.04.077 Guo X., Lin W., Wen W., Huyghe J., Bien S., Cai Q., Harrison T., Chen Z., Qu C., Bao J., Long J., 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