Cancer Genetics and Epigenetics 2024, Vol.12, No.6, 346-357 http://medscipublisher.com/index.php/cge 349 Figure 1 Prognosis of DNA methylation regulators and patterns of DNA methylation regulators modification.(Adapted from Pan et al., 2023) Image caption: (A) The correlation of 20 DNA methylation regulators in HCC patients; (B) The prognosis of 20 DNA methylation regulators in HCC patients; (C) The interaction among 20 DNA methylation regulators in HCC; The pink and blue line represents positive and negative correlation. The size of the circle represents the p value of the log-rank test; Green points represent favorable factors for OS; Purple points represent risk factors for OS; (D) The correlation between 20 DNA methylation regulators and 23 types of immune cells; (E) The consensus cluster matrix for patients with HCC; (F) The survival analysis for different patterns of patients; (G) PCA analysis indicated significant separation among three patterns; *P<0.05 (Adapted from Pan et al., 2023) 3.3 Mechanisms of methylation changes The mechanisms leading to methylation changes in HCC are influenced by both intrinsic genetic factors and external environmental exposures. Chronic liver diseases, such as hepatitis B and C, can induce DNA methylation changes that promote liver cancer development. Integration of viral genomes into the host DNA can lead to aberrant methylation of key promoter regions, silencing genes involved in immune surveillance, thus allowing liver cancer cells to evade immune responses (Zhang et al., 2015).
RkJQdWJsaXNoZXIy MjQ4ODYzNQ==