CGE_2024v12n5

Cancer Genetics and Epigenetics 2024, Vol.12, No.5, 270-278 http://medscipublisher.com/index.php/cge 276 https://doi.org/10.1002/ags3.12178 PMID: 30003187 PMCID: PMC6036382 Guo L.Y., Zhang S., Suo Z.H., Yang C.S., Zhao X., Zhang G.A., Hu D., Ji, X.Z., and Zhai M., 2015, PLCE1 gene in esophageal cancer and interaction with environmental factors, Asian Pacific Journal of Cancer Prevention, 16(7): 2745-2749. https://doi.org/10.7314/APJCP.2015.16.7.2745 PMID: 25854357 Han W.J., Li W.Y., and He Z.B., 2022, Association of GSTP1 and PLCE1 gene polymorphisms with primary esophageal cancer, Chinese Journal of Medical Genetics, 39(11): 1283-1289. https://doi.org/10.3760/cma.j.cn511374-20220330-00213 PMID: 36317220 Hao J.J., Lin D.C., Dinh H.Q., Mayakonda A., Jiang Y.Y., Chang C., Jiang Y., Lu C.C., Shi Z.Z., Xu X., Zhang Y., Cai Y., Wang J.W., Zhan Q.M., Wei W.Q., Berman B.P., Wang M.R., and Koeffler H.P., 2016, Spatial intratumor heterogeneity of genetic, epigenetic alterations and temporal clonal evolution in esophageal squamous cell carcinoma, Nature Genetics, 48(12): 1500-1507. https://doi.org/10.1038/ng.3683 PMID: 27749841 PMCID: PMC5127772 Hartenian E., and Doench J.G., 2015, Genetic screens and functional genomics using CRISPR/Cas9 technology, The FEBS Journal, 282(8): 1383-1393. https://doi.org/10.1111/febs.13248 PMID: 25728500 He W.Y., Leng X.F., Yang Y.Y., Peng L., Shao Y., Li X., and Han Y.T., 2020, Genetic heterogeneity of esophageal squamous cell carcinoma with inherited family history, OncoTargets and Therapy, 13: 8795-8802. https://doi.org/10.2147/OTT.S262512 PMID: 32943884 PMCID: PMC7481280 Kailasam A., Mittal S.K., and Agrawal D.K., 2015, Epigenetics in the pathogenesis of esophageal adenocarcinoma, Clinical and Translational Science, 8(4):394-402. https://doi.org/10.1111/cts.12242 PMID: 25388215 PMCID: PMC4429045 Kaz A.M., Wong C.J., Varadan V., Willis J.E., Chak A., and Grady W.M, 2016, Global DNA methylation patterns in Barrett’s esophagus, dysplastic Barrett’s, and esophageal adenocarcinoma are associated with BMI, gender, and tobacco use, Clinical Epigenetics, 8: 111. https://doi.org/10.1186/s13148-016-0273-7 PMID: 27795744 PMCID: PMC5082363 Kishino T., Niwa T., Yamashita S., Takahashi T., Nakazato H., Nakajima T., Igaki H., Tachimori Y., Suzuki Y., and Ushijima T, 2016, Integrated analysis of DNA methylation and mutations in esophageal squamous cell carcinoma, Molecular Carcinogenesis, 55(12): 2077-2088. https://doi.org/10.1002/mc.22452 PMID: 26756304 Li G.M., Song Q.Y., Jiang Y.X., Cai A.S., Tang Y., Tang N., Yi D.L., Zhang R., Wei Z.L., Liu D.X., Chen J., Zhang Y.Q., Liu L., Wu Y.Z., Zhang B., and Yi D., 2020, Cumulative evidence for associations between genetic variants and risk of esophageal cancer, Cancer Epidemiology Biomarkers and Prevention, 29(4): 838-849. https://doi.org/10.1158/1055-9965.EPI-19-1281 PMID: 31969372 Liu T.T., Li C.F., Tan K., Jan Y., Lee P.H., Huang C.H., Yu S.C., Tsao C., Wang J.C., and Huang H.Y., 2022, Characterization of aberrations in DNA damage repair pathways in gastrointestinal stromal tumors: The clinicopathologic relevance of γH2AX and 53BP1 in correlation with heterozygous deletions of CHEK2, BRCA2, and RB1, Cancers, 14(7): 1787. https://doi.org/10.3390/cancers14071787 PMID: 35406559 PMCID: PMC8997382 Ma P.F., Fu Y.J., Cai M.C., Yan Y., Jing Y., Zhang S., Chen M., Wu J., Shen Y., Zhu L., Chen H.Z., Gao W.Q., Wang M.Z., Gu Z., Bivona T.G., Zhao X., and Zhuang G., 2017, Simultaneous evolutionary expansion and constraint of genomic heterogeneity in multifocal lung cancer, Nature Communications, 8(1): 823. https://doi.org/10.1038/s41467-017-00963-0 PMID: 29018192 PMCID: PMC5634994 Murugaesu N., Wilson G.A., Birkbak N.J., Watkins T., McGranahan N., Kumar S., Abbassi-Ghadi N., Salm M., Mitter R., Horswell S., Rowan A., Phillimore B., Biggs J., Begum S., Matthews N., Hochhauser D., Hanna G.B., and Swanton C., 2015, Tracking the genomic evolution of esophageal adenocarcinoma through neoadjuvant chemotherapy, Cancer Discovery, 5(8): 821-831. https://doi.org/10.1158/2159-8290.CD-15-0412 PMID: 26003801 PMCID: PMC4529488 Mason J., 2024, High-throughput sequencing technology: a new chapter in epigenetics and disease research, Cancer Genetics and Epigenetics, 12(1): 47-54. https://doi.org/doi: 10.5376/cge.2024.12.0006 Mao N., Nie S.Y., Hong B., Li C., Shen X., and Xiong T, 2016, Association between alcohol dehydrogenase-2 gene polymorphism and esophageal cancer risk: a

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