CGE_2024v12n4

Cancer Genetics and Epigenetics 2024, Vol.12, No.4, 223-233 http://medscipublisher.com/index.php/cge 232 Carlo M., Hakimi A., Stewart G., Bratslavsky G., Brugarolas J., Chen Y., Linehan W., Maher E., Merino M., Offit K., Reuter V., Shuch B., and Coleman J., 2019, Familial kidney cancer: implications of new syndromes and molecular insights, European urology, 76(6): 754-764. https://doi.org/10.1016/j.eururo.2019.06.015 Coppin L., Plouvier P., Crépin M., Jourdain A., Yahya E., Richard S., Paillerets B., Cardot-Bauters C., Lejeune S., Leclerc J., and Pigny P., 2019, Optimization of next-generation sequencing technologies for von Hippel Lindau (VHL) mosaic mutation detection and development of confirmation methods, The Journal of Molecular Diagnostics, 21(3): 462-470. https://doi.org/10.1016/j.jmoldx.2019.01.005 Corrò C., Hejhal T., Poyet C., Sulser T., Hermanns T., Winder T., Prager G., Wild P., Frew I., Moch H., and Rechsteiner M., 2017, Detecting circulating tumor DNA in renal cancer: an 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Gupta R., Finelli A., and Jewett M.A., 2012, Needle core biopsies provide ample material for genomic and proteomic studies of kidney cancer: observations on DNA, RNA, protein extractions and VHL mutation detection, Pathology-Research and Practice, 208(1): 22-31. https://doi.org/10.1016/j.prp.2011.11.001 Lin F., Shi J., Liu H., Zhang J., Zhang P., Wang H., Yang X., and Schuerch C., 2008, Immunohistochemical detection of the von Hippel-Lindau gene product (pVHL) in human tissues and tumors: a useful marker for metastatic renal cell carcinoma and clear cell carcinoma of the ovary and uterus, American Journal of Clinical Pathology, 129(4): 592-605. https://doi.org/10.1309/Q0FLUXFJ4FTTW1XR Mazumder S., Higgins P., and Samarakoon R., 2023, Downstream targets of VHL/HIF-α signaling in renal clear cell carcinoma progression: mechanisms and therapeutic relevance, Cancers, 15(4): 1316. https://doi.org/10.3390/cancers15041316 Messai Y., Gad S., Noman M., Teuff G., Couvé S., Janji B., Kammerer S., Rioux-leclerc N., Hasmim M., Ferlicot S., Baud V., Méjean A., Mole D., Richard S., Eggermont A., Albiges L., Mami-Chouaib F., Escudier B., and Chouaib S., 2016, Renal cell carcinoma programmed death-ligand 1, a new direct target of hypoxia-inducible factor-2 alpha, is regulated by von Hippel-Lindau gene mutation status, European Urology, 70(4): 623-632. https://doi.org/10.1016/j.eururo.2015.11.029 Nickerson M., Jaeger E., Shi Y., Durocher J., Mahurkar S., Zaridze D., Matveev V., Janout V., Kollarova H., Bencko V., Navratilova M., szeszenia-Dabrowska N., Mates D., Mukeria A., Holcatova I., Schmidt L., Toro J., Karami S., Hung R., Gerard G., Linehan W., Merino M., Zbar B., Boffetta P., Brennan P., Rothman N., Chow W., Waldman F., and Moore L.E., 2008, Improved identification of von Hippel-Lindau gene alterations in clear cell renal tumors, Clinical Cancer Research, 14(15): 4726-4734. https://doi.org/10.1158/1078-0432.CCR-07-4921 Ordóñez-Navadijo Á., Fuertes-Yebra E., Acosta-Iborra B., 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