Cancer Genetics and Epigenetics 2024, Vol.12, No.2, 106-114 http://medscipublisher.com/index.php/cge 106 Review and Progress Open Access Mechanisms of Interaction Between Epigenetic Modifications and Cancer Genomics JieWang Zhuji People’s Hospital, Zhuji, 311800, Zhejiang, China Corresponding email: 2308763906@qq.com Cancer Genetics and Epigenetics, 2024, Vol.12, No.2 doi: 10.5376/cge.2024.12.0013 Received: 08 Mar., 2024 Accepted: 15 Apr., 2024 Published: 27 Apr., 2024 Copyright © 2024 Wang, This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Preferred citation for this article: Wang J., 2024, Mechanisms of interaction between epigenetic modifications and cancer genomics, Cancer Genetics and Epigenetics, 12(2):106-114 (doi: 10.5376/cge.2024.12.0013) Abstract The interaction mechanism between epigenetic modifications and cancer genomics is a highly anticipated topic in the current field of cancer research. With the continuous advancement of technology, researchers' in-depth understanding of these two fields provides new perspectives for revealing the occurrence and development of cancer. Epigenetic modifications and cancer genomics play a crucial regulatory role in cell fate, gene expression, and tumorigenesis. The application of high-throughput sequencing technology enables researchers to have a more comprehensive understanding of the distribution and impact of epigenetic modifications in the cancer genome. However, the current challenges faced by cancer research, such as cancer heterogeneity and treatment resistance, further indicate the urgency of in-depth research on this interaction mechanism. This review introduces the basic concepts of cancer genomics and epigenetic modifications, explores the regulatory role of epigenetic modifications in the occurrence and development of cancer, and discusses the mutual influence between epigenetic modifications and cancer genomics. The aim is to deepen the understanding of the molecular mechanisms of cancer and provide scientific basis for precision medicine and personalized treatment. Keywords Epigenetic modifications; Cancer genomics; DNA methylation; Cancer driving genes; Individualized treatment 1 Introduction In the field of contemporary medical research, cancer remains a highly focused topic. As a complex and diverse disease, the mechanisms of cancer development have always been a focal point for scientists. With the advancement of high-throughput sequencing technologies, research in cancer genomics has gradually unveiled the genomic abnormalities in cancer cells, such as gene mutations and chromosomal rearrangements. This field's development provides a theoretical foundation for personalized cancer treatment. However, relying solely on genomics cannot fully explain the complexity of cancer. Epigenetic modifications, as a key mechanism in gene expression regulation, have garnered significant interest from researchers. Epigenetic modifications include various forms such as DNA methylation, histone modifications, and non-coding RNA, which can rapidly and dynamically adjust gene expression levels (Wang et al., 2021). Therefore, understanding the regulatory role of epigenetics in cancer and its interaction with genomics is crucial for revealing the comprehensive mechanisms of cancer. Research indicates that cancer development is a multifactorial and multistep process (Zou et al., 2019), involving the combined effects of gene mutations, epigenetic modifications, environmental factors, and more. Amidst this complexity, the interplay between cancer genomics and epigenetics has become a highly anticipated research direction. Cancer cells often exhibit genomic instability, and abnormal epigenetic modifications may be one of the critical reasons for this instability. Although significant progress has been made in the independent studies of cancer genomics and epigenetics, understanding how they interact and their roles throughout cancer development remains limited. In-depth research into these interaction mechanisms will aid in a more comprehensive understanding of cancer complexity and provide new insights for future therapeutic strategies. By reviewing existing literature and studies, this research aims to elucidate the close relationship between these two levels and explore their significance in cancer
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