Cancer Genetics and Epigenetics 2024, Vol.12, No.2, 88-96 http://medscipublisher.com/index.php/cge 91 fragments, reflecting that circulating cfDNA is a mixture of tumor cfDNA and cfDNA from other cells in the body. Sequencing of tissue samples confirmed that this region was almost completely methylated. This approach utilizes an extensive database to identify genomic regions that reliably indicate the presence of cancer, aiding in early diagnosis and potentially improving patient outcomes. The use of cfDNA methylation not only provides a non-invasive diagnostic tool, but also enhances our understanding of cancer biology at the molecular level. Figure 1 The CCGA study for development and validation of a cfDNA-based assay for multi-cancer detection (Adopted from Liu et al., 2020) Image caption: (A) CCGA study design. (B) Methylation biology discriminates cancer from non-cancer. (C) Target selection (Adopted from Liu et al., 2020)
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