Cancer Genetics and Epigenetics 2024, Vol.12, No.1, 37-46 http://www.medscipublisher.com/index.php/cge 45 7.2 Outlook and suggestions for future research directions In the face of these challenges, future research should focus on several aspects. Firstly, there is a need to enhance the specificity and sensitivity of molecular markers. This could be achieved through the combination of multiple markers and the utilization of more advanced bioinformatics methods. Additionally, exploring novel markers associated specifically with gastric cancer, such as non-coding RNA and circulating DNA, should be a key research direction in the future. Secondly, research efforts should be directed towards reducing the cost and enhancing the accessibility of the technologies. This involves not only improving the cost-effectiveness of existing technologies but also developing new, more economical diagnostic approaches. For instance, the use of portable or miniaturized devices for genomic or proteomic analysis could be a promising direction. In terms of data processing, strengthening the application of artificial intelligence and machine learning in data analysis will be crucial. Developing more advanced algorithms to handle and interpret complex biomedical data can improve the accuracy and efficiency of diagnostics. Finally, it is essential to reinforce clinical trials and standardization of emerging technologies. This not only accelerates the clinical application of new technologies but also provides clear guidance and standards for clinicians. Interdisciplinary collaboration is also crucial, as it facilitates the exchange of knowledge and technology among experts from different fields, collectively advancing the development of early gastric cancer diagnostic technologies. In conclusion, despite facing numerous challenges, the future of emerging technologies in early gastric cancer diagnosis remains promising. Through interdisciplinary collaboration, technological innovation, and ongoing research, we can expect to achieve more accurate, cost-effective, and universally applicable methods for early gastric cancer diagnosis in the near future. References Chang Y.H., Shin C.M., Lee H.D., Park J.B., Jeon J., Kang S., and Kim N., 2023, Clinical evaluation of an artificial intelligence system for upper gastrointestinal endoscopy on detecting and diagnosing gastric lesions pathologically pre-diagnosed with atypia and gastric dysplasia: a pilot study, Gastrointestinal Endoscopy, 97(6): AB764. https://doi.org/10.1016/j.gie.2023.04.1250 Chen C., Shi C., Huang X., Zheng J., Zhu Z., Li Q., Qiu S, Huang Z.Q., Zhuang Z.K., Wu R.P., Liu P.H., Wu F., Lin S.Y., Li B., and Chen Q., 2019, Molecular profiles and metastasis markers in Chinese patients with gastric carcinoma, Scientific Reports, 9(1): 13995. https://doi.org/10.1038/s41598-019-50171-7 PMid:31570735 PMCid:PMC6769015 Guo S.J., Gao M., Li Y.B., and Li Z., 2019, Application of contrast-enhanced ultrasound combined with multi-slice spiral CT in the diagnosis of gastric cancer, Zhonguo CT and MRI Zazhi (Chinese Journal of CT and MRI), 17(6): 130-132. Liu S., Jiang X., Shang Z., Ji Y., Wang H., Wang Z., Wang P., Zhang Y., and Xiao H., 2020, N-glycan structures of target cancer biomarker characterized by two-dimensional gel electrophoresis and mass spectrometry, Analytica Chimica Acta, 1123: 18-27. https://doi.org/10.1016/j.aca.2020.04.063 PMid:32507236 Lu Y., Li D.H., and Yang W.L., 2022, Research progress on circular RNAs as molecular markers for gastric cancer, Zhongguo Zhongliu Linchuan (Chinese Journal of Clinical Oncology), 49(3): 150-154. Mitani S., and Kawakami H., 2020, Emerging targeted therapies for HER2 positive gastric cancer that can overcome trastuzumab resistance, Cancers, 12(2): 400. https://doi.org/10.3390/cancers12020400 PMid:32050652 PMCid:PMC7072407 Pijl J.P., Nienhuis P.H., Kwee T.C., Glaudemans A.W., Slart R.H., and Gormsen L.C., 2021, Limitations and pitfalls of FDG-PET/CT in infection and inflammation, In Seminars in Nuclear Medicine, 51(6): 633-645. Sekiguchi M., Oda I., Matsuda T., and Saito Y., 2022, Epidemiological trends and future perspectives of gastric cancer in Eastern Asia, Digestion, 103(1): 22-28. https://doi.org/10.1159/000518483 PMid:34515086
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