Cancer Genetics and Epigenetics 2024, Vol.12, No.1, 15-26 http://www.medscipublisher.com/index.php/cge 15 Research Article Open Access The Exploration of Immunotherapy Methods for Endometrial Cancer Ningmeng Guo, Jialan Guo, Shoukai Wang Zhejiang Medicine Co., Ltd., Shaoxing, 312072, China Corresponding author email: 240046250@qq.com Cancer Genetics and Epigenetics, 2024, Vol.12, No.1 doi: 10.5376/cge.2024.12.0003 Received: 01 Dec., 2023 Accepted: 02 Jan., 2024 Published: 15 Jan., 2024 Copyright © 2024 Guo et al., This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Preferred citation for this article: Guo N.M., Guo J.L., and Wang S.K., 2024, The exploration of immunotherapy methods for endometrial cancer, Cancer Genetics and Epigenetics, 12(1): 15-26 (doi: 10.5376/cge.2024.12.0003) Abstract Immunotherapy holds significant importance and broad prospects in the treatment of endometrial cancer. Traditional treatment methods have limited efficacy for advanced or recurrent patients, while immunotherapy can activate the patient's own immune system to attack tumor cells, offering more precise and effective treatment outcomes. Personalized immunotherapy can select the most suitable treatment plan based on the patient's immune and tumor characteristics, improving therapeutic effects and reducing side effects. Immunotherapy demonstrates enduring treatment effects, prolonging patient survival and enhancing quality of life. Combined with other treatment modalities, immunotherapy forms a comprehensive therapeutic strategy, augmenting treatment efficacy. Future research and innovation will further drive the application of immunotherapy in the treatment of endometrial cancer. The purpose of this research is to provide a comprehensive understanding of the disease, analyze the efficacy and safety of existing methods, and explore future research directions and challenges. Through the presentation and analysis of these contents, valuable information and references can be provided to the public, promoting research and application of immunotherapy for endometrial cancer and advancing medical progress and treatment innovation. Keywords Immunotherapy; Endometrial cancer; Personalized treatment; Persistent effects; Comprehensive therapy Endometrial cancer is one of the most common gynecological malignancies in women, mainly occurring in endometrial tissue. Although early endometrial cancer usually has a good prognosis, the treatment of advanced or recurrent endometrial cancer remains a challenge. At present, the main treatment methods for endometrial cancer include surgical resection, radiotherapy, and chemotherapy. However, these traditional treatment methods have some limitations and side effects. Surgery is effective for early cases, but the treatment effect for advanced or recurrent endometrial cancer is limited. Although radiotherapy and chemotherapy can control disease progression, they are often accompanied by severe toxic side effects and the development of drug resistance. Finding more effective treatment methods is one of the focuses of current research on endometrial cancer. In this context, immunotherapy is considered a promising option. By regulating the function of the immune system, immunotherapy can provide better treatment outcomes and survival rates for patients with endometrial cancer. In summary, the importance and potential of immunotherapy in cancer treatment have been widely recognized. Immunotherapy provides a new treatment approach and possibility for the treatment challenge of endometrial cancer. This research will explore immunotherapy strategies for endometrial cancer, including immune checkpoint inhibitors, tumor vaccines, and CAR-T cell therapy, and discuss their progress and challenges in clinical application and efficacy evaluation. Endometrial cancer is currently one of the main health issues for women, posing a huge burden on both patients and the medical community. Although traditional cancer treatment methods such as surgery, radiotherapy, and chemotherapy have achieved certain results to some extent, there are still many challenges and limitations. In recent years, immunotherapy, as an emerging treatment method, has attracted widespread attention and research, and its importance and potential in cancer treatment have been highly recognized. This research discusses the progress of immunotherapy for endometrial cancer, including different treatment methods such as immune checkpoint inhibitors, immune cell therapies, vaccines, and immune modifiers. The aim is to convey to readers the
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