MPR_2025v15n6

Medicinal Plant Research 2025, Vol.15, No.6, 283-290 http://hortherbpublisher.com/index.php/mpr 290 Sharma B., and Yadav D., 2022, Metabolomics and network pharmacology in the exploration of the multi-targeted therapeutic approach of traditional medicinal plants, Plants, 11(23): 3243. https://doi.org/10.3390/plants11233243 Shi L., Chen X., Cao H., Tian C., Zou L., Yu J., Lu Z., Zhao W., Liu J., and Yu L., 2023, N-Butanol extract of Glycyrrhizae radix et rhizoma inhibits dengue virus through targeting envelope protein, Pharmaceuticals, 16(2): 263. https://doi.org/10.3390/ph16020263 Shinu P., Gupta G., Sharma M., Khan S., Goyal M., Nair A., Kumar M., Soliman W., Rahman A., Attimarad M., Venugopala K., and Altaweel A., 2023, Pharmacological features of 18β-glycyrrhetinic acid: A pentacyclic triterpenoid of therapeutic potential, Plants, 12(5): 1086. https://doi.org/10.3390/plants12051086 Simayi Z., Rozi P., Yang X., Ababaikeri G., Maimaitituoheti W., Bao X., Sai S., Askar G., and Yadikar N., 2021, Isolation, structural characterization, biological activity, and application of Glycyrrhiza polysaccharides: Systematic review, International Journal of Biological Macromolecules, 183: 1425-1440. https://doi.org/10.1016/j.ijbiomac.2021.04.099 Stecanella L., Bitencourt A., Vaz G., Quarta E., Júnior J., and Rossi A., 2021, Glycyrrhizic acid and its hydrolyzed metabolite 18β-glycyrrhetinic acid as specific ligands for targeting nanosystems in the treatment of liver cancer, Pharmaceutics, 13(11): 1792. https://doi.org/10.3390/pharmaceutics13111792 Sun J., Zhang Q., Yang G., Li Y., Fu Y., Zheng Y., and Jiang X., 2022, The licorice flavonoid isoliquiritigenin attenuates Mycobacterium tuberculosis-induced inflammation through Notch1/NF-κB and MAPK signaling pathways, Journal of Ethnopharmacology, 293: 115368. https://doi.org/10.1016/j.jep.2022.115368 Sun Z., Zhao T., Lu N., Yang Y., and Zhu H., 2019, Research progress of Glycyrrhizic acid on antiviral activity, Mini Reviews in Medicinal Chemistry, 19(1): 45-53. https://doi.org/10.2174/1389557519666190119111125 Tong T., Hu H., Zhou J., Deng S., Zhang X., Tang W., Fang L., Xiao S., and Liang J., 2020, Glycyrrhizic-acid-based carbon dots with high antiviral activity by multisite inhibition mechanisms, Small, 16(32): 1906206. https://doi.org/10.1002/smll.201906206 Toussaint P., Leiser F., Thiebes S., Schlesner M., Brors B., and Sunyaev A., 2023, Explainable artificial intelligence for omics data: a systematic mapping study, Briefings in Bioinformatics, 25(6): bbad453. https://doi.org/10.1093/bib/bbad453 Wu S., Yang G., Wang K., Yan H., Wang H., Li X., Qiao L., Wu M., Wang Y., Jiang J., and Li Y., 2025, Diammonium glycyrrhizinate exerts broad-spectrum antiviral activity against human coronaviruses by interrupting spike-mediated cellular entry, International Journal of Molecular Sciences, 26(13): 6334. https://doi.org/10.3390/ijms26136334 Yan S., Bhawal R., Yin Z., Thannhauser T., and Zhang S., 2022, Recent advances in proteomics and metabolomics in plants, Molecular Horticulture, 2: 38. https://doi.org/10.1186/s43897-022-00038-9 Yao H., Wang F., Bi Q., Liu H., Liu L., Xiao G., Zhu J., Shen H., and Li H., 2022, Combined analysis of pharmaceutical active ingredients and transcriptomes of Glycyrrhiza uralensis under PEG6000-induced drought stress revealed Glycyrrhizic acid and flavonoids accumulation via JA-mediated signaling, Frontiers in Plant Science, 13: 920172. https://doi.org/10.3389/fpls.2022.920172 Zendejas-Hernandez U., Alcántara-Martínez N., Vivar D., Valenzuela F., Espinoza A., and Ceballos E., 2024, Nebulized glycyrrhizin/enoxolone drug modulates IL-17A in COVID-19 patients: a randomized clinical trial, Frontiers in Immunology, 14: 1282280. https://doi.org/10.3389/fimmu.2023.1282280 Zhao Z., Xiao Y., Xu L., Liu Y., Jiang G., Wang W., Li B., Zhu T., Tan Q., Tang L., Zhou H., Huang X., and Shan H., 2021, Glycyrrhizic acid nanoparticles as antiviral and anti-inflammatory agents for COVID-19 treatment, ACS Applied Materials & Interfaces, 13(17): 20995-21006. https://doi.org/10.1021/acsami.1c02755 Zhou G., Qin M., Liu X., Qi Y., Ou X., and Tang M., 2025, De novo assembly of the mitochondrial genome of Glycyrrhiza glabra and identification of two types of homologous recombination configurations caused by repeat sequences, BMC Genomics, 26: 190. https://doi.org/10.1186/s12864-024-11190-5

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