MPR_2025v15n5

Medicinal Plant Research 2025, Vol.15, No.5, 233-243 http://hortherbpublisher.com/index.php/mpr 243 Ren J., Fu L., Nile S.H., Zhang J., and Kai G., 2019, Salvia miltiorrhiza in treating cardiovascular diseases: a review on its pharmacological and clinical applications, Frontiers in Pharmacology, 10: 753. https://doi.org/10.3389/fphar.2019.00753 Shan X., Li J., Hong B., Yin H., Lu Z., Wang G., Yu N., Peng D., Wang L., Zhang C., and Chen W., 2024, Comparative efficacy of sweated and non-sweated Salvia miltiorrhiza Bge. extracts on acute myocardial ischemia via regulating the PPARα/RXRα/NF-κB signaling pathway, Heliyon, 10(11): e31923. https://doi.org/10.1016/j.heliyon.2024.e31923 Shen Y., Shen X., Wang S., Zhang Y., Wang Y., Ding Y., Shen J., Zhao J., Qin H., Xu Y., Zhou Q., Wang X., and Shen J., 2022, Protective effects of salvianolic acid B on rat ferroptosis in myocardial infarction through upregulating the Nrf2 signaling pathway, International Immunopharmacology, 112: 109257. https://doi.org/10.1016/j.intimp.2022.109257 Shi M., Huang F., Deng C., Wang Y., and Kai G., 2019, Bioactivities, biosynthesis and biotechnological production of phenolic acids in Salvia miltiorrhiza, Critical Reviews in Food Science and Nutrition, 59(6): 953-964. https://doi.org/10.1080/10408398.2018.1474170 Tao H., Yang X., Wang W., Yue S., Pu Z., Huang Y., Shi X., Chen J., Zhou G., Chen Y., Zhao M., Tang Y., and Duan J., 2019, Regulation of serum lipidomics and amino acid profiles of rats with acute myocardial ischemia by Salvia miltiorrhiza and Panax notoginseng herb pair, Phytomedicine, 67: 153162. https://doi.org/10.1016/j.phymed.2019.153162 Wang L., Ma R., Liu C., Liu H., Zhu R., Guo S., Tang M., Li Y., Niu J., Fu M., Gao S., and Zhang D., 2017, Salvia miltiorrhiza: a potential red light to the development of cardiovascular diseases, Current Pharmaceutical Design, 23(7): 1077-1097. https://doi.org/10.2174/1381612822666161010105242 Wei B., Sun C., Wan H., Shou Q., Han B., Sheng M., Li L., and Kai G., 2023, Bioactive components and molecular mechanisms of Salvia miltiorrhiza Bunge in promoting blood circulation to remove blood stasis, Journal of Ethnopharmacology, 317: 116697. https://doi.org/10.1016/j.jep.2023.116697 Wu C.F., Karioti A., Rohr D., Bilia A.R., and Efferth T., 2016, Production of rosmarinic acid and salvianolic acid B from callus culture of Salvia miltiorrhiza with cytotoxicity towards acute lymphoblastic leukemia cells, Food Chemistry, 201: 292-297. https://doi.org/10.1016/j.foodchem.2016.01.054 Wu Y., Zhang G., Li L., Liu B., Wang R., Song R., Hua Y., Bi Y., Han X., Zhang F., Wang D., Xie L., and Zhou Y., 2024, Salvia miltiorrhiza suppresses cardiomyocyte ferroptosis after myocardial infarction by activating Nrf2 signaling, Journal of Ethnopharmacology, 330: 118214. https://doi.org/10.1016/j.jep.2024.118214 Ye Z., Liu Y., Song J., Gao Y., Fang H., Hu Z., Zhang M., Liao W., Cui L., and Liu Y., 2023, Expanding the therapeutic potential of Salvia miltiorrhiza: a review of its pharmacological applications in musculoskeletal diseases, Frontiers in Pharmacology, 14: 1276038. https://doi.org/10.3389/fphar.2023.1276038 Zhang L., Han L., Wang X., Wei Y., Zheng J., Zhao L., and Tong X., 2021, Exploring the mechanisms underlying the therapeutic effect of Salvia miltiorrhiza in diabetic nephropathy using network pharmacology and molecular docking, Bioscience Reports, 41(6): BSR20203520. https://doi.org/10.1042/BSR20203520 Zhang M., Liu Y., Sun X., Zhang X., and Hua L., 2025, Salvia miltiorrhiza adjuvant therapy facilitates cardiac function recovery in patients with myocardial infarction, Pakistan Journal of Pharmaceutical Sciences, 38(1): 45-54. Zhang M.X., Huang X.Y., Song Y., Xu W.L., Li Y.L., and Li C., 2023, Astragalus propinquus Schischkin and Salvia miltiorrhiza Bunge promote angiogenesis to treat myocardial ischemia via Ang-1/Tie-2/FAK pathway, Frontiers in Pharmacology, 13: 1103557. https://doi.org/10.3389/fphar.2022.1103557 Zhong L., Dong L., Sun J., Yang J., Yu Z., He P., Zhu B., Zhu Y., Li S., and Xu W., 2024, Network pharmacology and subsequent experimental validation reveal the synergistic myocardial protection mechanism of Salvia miltiorrhiza Bge. and Carthamus tinctorius L., Journal of Traditional Chinese Medical Sciences, 11(1): 44-54. https://doi.org/10.1016/j.jtcms.2023.11.003 Zhou R., He L.F., Li Y.J., Shen Y., Chao R.B., and Du J.R., 2012, Cardioprotective effect of water and ethanol extract of Salvia miltiorrhiza in an experimental model of myocardial infarction, Journal of Ethnopharmacology, 139(2): 440-446. https://doi.org/10.1016/j.jep.2011.11.030 Zhou W., Shi M., Deng C., Lu S., Huang F., Wang Y., and Kai G., 2021, The methyl jasmonate-responsive transcription factor SmMYB1 promotes phenolic acid biosynthesis in Salvia miltiorrhiza, Horticulture Research, 8: 443. https://doi.org/10.1038/s41438-020-00443-5

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