MPR_2025v15n5

Medicinal Plant Research 2025, Vol.15, No.5, 233-243 http://hortherbpublisher.com/index.php/mpr 242 Huang W., Yang Y., Zeng Z., Su M., Gao Q., and Zhu B., 2016, Effect of Salvia miltiorrhiza and ligustrazine injection on myocardial ischemia/reperfusion and hypoxia/reoxygenation injury, Molecular Medicine Reports, 14(5): 4537-4544. https://doi.org/10.3892/mmr.2016.5822 Huang X., Zhang M., Song Y., Sun B., Lin L., Song X., and Li C., 2023, Integrated network pharmacology to investigate the mechanism of Salvia miltiorrhiza Bunge in the treatment of myocardial infarction, Journal of Cellular and Molecular Medicine, 27(22): 3514-3525. https://doi.org/10.1111/jcmm.17932 Hung Y.C., Wang P.W., Lin T.Y., Yang P.M., You J.S., and Pan T.L., 2020, Functional redox proteomics reveal that Salvia miltiorrhiza aqueous extract alleviates adriamycin-induced cardiomyopathy via inhibiting ROS-dependent apoptosis, Oxidative Medicine and Cellular Longevity, 2020(1): 5136934. https://doi.org/10.1155/2020/5136934 Jiang Z., Gao W., and Huang L., 2019, Tanshinones, critical pharmacological components in Salvia miltiorrhiza, Frontiers in Pharmacology, 10: 202. https://doi.org/10.3389/fphar.2019.00202 Jung I., Kim H., Moon S., Lee H., and Kim B., 2020, Overview of Salvia miltiorrhiza as a potential therapeutic agent for various diseases: an update on efficacy and mechanisms of action, Antioxidants, 9(9): 857. https://doi.org/10.3390/antiox9090857 Li B., Li J., Chai Y., Huang Y., Li L., Wang D., and Wang Z., 2021, Targeted mutagenesis of CYP76AK2 and CYP76AK3 in Salvia miltiorrhiza reveals their roles in tanshinones biosynthetic pathway, International Journal of Biological Macromolecules, 189: 455-463. https://doi.org/10.1016/j.ijbiomac.2021.08.112 Li H., Jiang X., Mashiguchi K., Yamaguchi S., and Lu S., 2024, Biosynthesis and signal transduction of plant growth regulators and their effects on bioactive compound production in Salvia miltiorrhiza (Danshen), Chinese Medicine, 19(1): 102. https://doi.org/10.1186/s13020-024-00971-5 Li Q., Ren C., Jiang B., Wang X., Wang C., Zhi X., Li L., Guo X., Zhao X., and Li Y., 2025, Salvia miltiorrhiza Bunge root in the treatment of myocardial fibrosis: research progress and challenges, Frontiers in Pharmacology, 16: 1554696. https://doi.org/10.3389/fphar.2025.1554696 Li X., Liu R., Liu W., Liu X., Fan Z., Cui J., Wu Y., Yin H., and Lin Q., 2023, Panax quinquefoliumL. and Salvia miltiorrhiza Bunge enhances angiogenesis by regulating the miR-155-5p/HIF-1α/VEGF axis in acute myocardial infarction, Drug Design, Development and Therapy, 17: 3249-3267. https://doi.org/10.2147/DDDT.S426345 Li Z.M., Xu S.W., and Liu P.Q., 2018, Salvia miltiorrhiza Burge (Danshen): a golden herbal medicine in cardiovascular therapeutics, Acta Pharmacologica Sinica, 39(5): 802-824. https://doi.org/10.1038/aps.2017.193 Lin R., Mu F., Li Y., Duan J., Zhao M., Guan Y., Liu K., Bai Y., Wen A., Wei P., Wang J., and Xi M., 2021, Salvia miltiorrhiza and the volatile of Dalbergia odorifera attenuate chronic myocardial ischemia injury in a pig model: a metabonomic approach for the mechanism study, Oxidative Medicine and Cellular Longevity, 2021(1): 8840896. https://doi.org/10.1155/2021/8840896 Liu Y., Huang J., Sujie L., Chen Y., Yang Z., Wang J., and Zhao T., 2023, To explore the mechanism of Salvia miltiorrhiza in preventing liver fibrosis based on angiogenesis, Medical Research Frontiers, 2(4): 189. https://doi.org/10.57237/j.mrf.2023.04.006 Lu S., 2021, Biosynthesis and regulatory mechanisms of bioactive compounds in Salvia miltiorrhiza, a model system for medicinal plant biology, Critical Reviews in Plant Sciences, 40(3): 243-283. https://doi.org/10.1080/07352689.2021.1935719 Luo L., Xue J., Shao Z., Zhou Z., Tang W., Liu J., Hu H., and Yang F., 2023, Recent developments in Salvia miltiorrhiza polysaccharides: isolation, purification, structural characteristics and biological activities, Frontiers in Pharmacology, 14: 1139201. https://doi.org/10.3389/fphar.2023.1139201 Meng H., Wu J., Shen L., Chen G., Jin L., Yan M., Wan H., and He Y., 2022, Microwave assisted extraction, characterization of a polysaccharide fromSalvia miltiorrhiza Bunge and its antioxidant effects via ferroptosis-mediated activation of the Nrf2/HO-1 pathway, International Journal of Biological Macromolecules, 215: 398-412. https://doi.org/10.1016/j.ijbiomac.2022.06.064 Mu F., Duan J., Bian H., Yin Y., Zhu Y., Wei G., Guan Y., Wang Y., Guo C., Wen A., Yang Y., and Xi M., 2017, Cardioprotective effects and mechanism of Radix Salvia miltiorrhiza and Lignum Dalbergiae odoriferae on rat myocardial ischemia/reperfusion injury, Molecular Medicine Reports, 16(2): 1759-1770. https://doi.org/10.3892/mmr.2017.6821 Mu X., Yu H., Li H., Feng L., Ta N., Ling L., Bai L., A.R., Borjigidai A., Pan Y., and Fu M., 2024, Metabolomics analysis reveals the effects of Salvia miltiorrhiza Bunge extract on ameliorating acute myocardial ischemia in rats induced by isoproterenol, Heliyon, 10(9): e30488. https://doi.org/10.1016/j.heliyon.2024.e30488 Qian C., Huang Y., Zhang S., Yang C., Zheng W., Tang W., Wan G., Wang A., Lu Y., and Zhao Y., 2025, Integrated identification and mechanism exploration of bioactive ingredients fromSalvia miltiorrhiza to induce vascular normalization, Phytomedicine, 138: 156427. https://doi.org/10.1016/j.phymed.2025.156427

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