MPR_2025v15n4

Medicinal Plant Research 2025, Vol.15, No.4, 188-196 http://hortherbpublisher.com/index.php/mpr 195 Huang Y., Tsay H., Lu M., Lin C., Yeh C., Liu H., and Shiao Y., 2017, Astragalus membranaceus polysaccharides ameliorate obesity, hepatic steatosis, neuroinflammation, and cognitive impairment without affecting amyloid deposition in metabolically stressed APPswe/PS1dE9 mice, International Journal of Molecular Sciences, 18(12): 2746. https://doi.org/10.3390/ijms18122746 Li M., Han B., Zhao H., Xu C., Xu D., Sieniawska E., Lin X., and Kai G., 2022, Biological active ingredients of Astragali radix and its mechanisms in treating cardiovascular and cerebrovascular diseases, Phytomedicine, 98: 153918. https://doi.org/10.1016/j.phymed.2021.153918 Li S., Hu X., Liu F., and Hu W., 2025, Bioactive components and clinical potential of Astragalus species, Frontiers in Pharmacology, 16: 1585697. https://doi.org/10.3389/fphar.2025.1585697 Liang H., Chen Z., Zhu M., Zhong J., Lin S., Chen J., Yuan J., Jiang P., Zhao X., and Xiao Y., 2025, Efficacy and potential pharmacological mechanism of Astragalus-Salvia miltiorrhiza combination in diabetic nephropathy: Integrating meta-analysis, network pharmacology, molecular docking, and experimental validation, Renal Failure, 47: 2466116. https://doi.org/10.1080/0886022X.2025.2466116 Liu D., Chen L., Zhao J., and Cui K., 2018, Cardioprotection activity and mechanism of Astragalus polysaccharide in vivo and in vitro, International Journal of Biological Macromolecules, 111: 947-952. https://doi.org/10.1016/j.ijbiomac.2018.01.048 Liu M., Di Y., May B., Zhang A., Zhang L., Chen J., Wang R., Liu X., and Xue C., 2024, Renal protective effects and mechanisms of Astragalus membranaceus for diabetic kidney disease in animal models: An updated systematic review and meta-analysis, Phytomedicine: International Journal of Phytotherapy and Phytopharmacology, 129: 155646. https://doi.org/10.1016/j.phymed.2024.155646 Qiu T., Toumi M., Zhang S., Yang X., and Yan D., 2025, Effectiveness and safety of Astragalus-containing Chinese medicine combined with Western medicine for diabetes: A systematic review and meta-analysis, Current Traditional Medicine. https://doi.org/10.2174/0122150838346844250109164504 Shen Z., Cui T., Liu Y., Wu S., Han C., and Li J., 2023, Astragalus membranaceus and Salvia miltiorrhiza ameliorate diabetic kidney disease via the "gut-kidney axis", Phytomedicine: International Journal of Phytotherapy and Phytopharmacology, 121: 155129. https://doi.org/10.1016/j.phymed.2023.155129 Sheng X., Yang L., Huang B., Lin G., Wang Y., Wu X., and Lin R., 2025, Efficacy of Astragalus membranaceus (Huang Qi) for cancer-related fatigue: A systematic review and meta-analysis of randomized controlled studies, Integrative Cancer Therapies, 24. https://doi.org/10.1177/15347354241313344 Su H., Shaker S., Kuang Y., Zhang M., Ye M., and Qiao X., 2021, Phytochemistry and cardiovascular protective effects of Huang‐Qi (Astragali radix), Medicinal Research Reviews, 41: 1999-2038. https://doi.org/10.1002/med.21785 Su M., Tang T., Tang W., Long Y., Wang L., and Liu M., 2023, Astragalus improves intestinal barrier function and immunity by acting on intestinal microbiota to treat T2DM: A research review, Frontiers in Immunology, 14: 1243834. https://doi.org/10.3389/fimmu.2023.1243834 Sun S., Yang S., An N., Wang G., Xu Q., Liu J., and Mao Y., 2019, Astragalus polysaccharides inhibit cardiomyocyte apoptosis during diabetic cardiomyopathy via the endoplasmic reticulum stress pathway, Journal of Ethnopharmacology, 238: 111857. https://doi.org/10.1016/j.jep.2019.111857 Tan Y., Chen H., and Li J., 2020, Astragaloside IV: An effective drug for the treatment of cardiovascular diseases, Drug Design, Development and Therapy, 14: 3731-3746. https://doi.org/10.2147/DDDT.S272355 Tian H., An L., Wang P., Zhang X., Gao W., and Li X., 2024, Review of Astragalus membranaceus polysaccharides: Extraction process, structural features, bioactivities and applications, Chinese Herbal Medicines, 17(1): 56-69. https://doi.org/10.1016/j.chmed.2024.09.004 Wang C., Li S., Meng J., Xia M., Bo Q., and Ying W., 2023, Meta-analysis of Huangqi (Astragalus membranaceus) and Chinese yam (Rhizoma Dioscoreae) for diabetic nephropathy, Alternative Therapies in Health and Medicine, 29(8): 840-845. Wang E., Wang L., Ding R., Zhai M., Ge R., Zhou P., Wang T., Fang H., Wang J., and Huang J., 2020, Astragaloside IV acts through multi-scale mechanisms to effectively reduce diabetic nephropathy, Pharmacological Research, 157: 104831. https://doi.org/10.1016/j.phrs.2020.104831 Wang L., Zheng W., Yang J., Ali A., and Qin H., 2022, Mechanism of Astragalus membranaceus alleviating acquired hyperlipidemia induced by high-fat diet through regulating lipid metabolism, Nutrients, 14(5): 954. https://doi.org/10.3390/nu14050954 Xu Z., Zhou H., Zhang Y., Cheng Z., Wan M., Qin W., Li P., Feng J., Shao S., Xue W., Guo H., and Liu B., 2023, Recent pharmacological advances in the treatment of cardiovascular events with Astragaloside IV, Biomedicine & Pharmacotherapy, 168: 115752. https://doi.org/10.1016/j.biopha.2023.115752

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