MPR_2025v15n4

Medicinal Plant Research 2025, Vol.15, No.4, 178-187 http://hortherbpublisher.com/index.php/mpr 186 Kim Y.J., Lee J.Y., Kim H.J., Kim D.H., Lee T.H., Kang M.S., and Park W., 2018, Anti-inflammatory effects of Angelica sinensis (Oliv.) Diels water extract on RAW 264.7 induced with lipopolysaccharide, Nutrients, 10(5): 647. https://doi.org/10.3390/nu10050647 Li K., Wang J., Huang Z., and Tan C., 2023, Morphology, solid structure and antioxidant activity in vitro of Angelica sinensis polysaccharide-Ce (IV), Chemistry and Biodiversity, 20(3): e202200813. https://doi.org/10.1002/cbdv.202200813 Li M.M., Zhang Y., Wu J., and Wang K.P., 2020, Polysaccharide from Angelica sinensis suppresses inflammation and reverses anemia in complete Freund’s adjuvant-induced rats, Current Medical Science, 40(2): 265-274. https://doi.org/10.1007/s11596-020-2183-3 Liu W., Li W., Sui Y., Li X., Liu C., Jing H., Zhang H., and Cao W., 2019, Structure characterization and anti-leukemia activity of a novel polysaccharide from Angelica sinensis (Oliv.) Diels, International Journal of Biological Macromolecules, 121: 161-172. https://doi.org/10.1016/j.ijbiomac.2018.09.213 Liu W., Li Z., Feng C., Hu S., Yang X., Xiao K., Nong Q., Xiao Q., Wu K., Li X., and Cao W., 2021, The structures of two polysaccharides from Angelica sinensis and their effects on hepatic insulin resistance through blocking RAGE, Carbohydrate Polymers, 280: 119001. https://doi.org/10.1016/j.carbpol.2021.119001 Luo L., Zhang H., Chen W., Zheng Z., He Z., Wang H., Wang K., and Zhang Y., 2023, Angelica sinensis polysaccharide ameliorates nonalcoholic fatty liver disease via restoring estrogen-related receptor α expression in liver, Phytotherapy Research, 37(11): 5407-5417. https://doi.org/10.1002/ptr.7982 Nai J., Zhang C., Shao H., Li B., Li H., Gao L., Dai M., Zhu L., and Sheng H., 2021, Extraction, structure, pharmacological activities and drug carrier applications of Angelica sinensis polysaccharide, International Journal of Biological Macromolecules, 183: 2337-2353. https://doi.org/10.1016/j.ijbiomac.2021.05.213 Ni S., Yi N., Yuan H., Li D., Chen X., and Zhuang C., 2023, Angelica sinensis polysaccharide improves mitochondrial metabolism of osteoarthritis chondrocytes through PPARγ/SOD2/ROS pathways, Phytotherapy Research, 37(11): 5394-5406. https://doi.org/10.1002/ptr.7979 Pan S., Jiang L., and Wu S., 2018, Stimulating effects of polysaccharide from Angelica sinensis on the nonspecific immunity of white shrimps (Litopenaeus vannamei), Fish and Shellfish Immunology, 74: 170-174. https://doi.org/10.1016/j.fsi.2017.12.067 Ren C., Luo Y., Li X., L., Wang C., Zhi X., Zhao X., and Li Y., 2025, Pharmacological action of Angelica sinensis polysaccharides: a review, Frontiers in Pharmacology, 15: 1510976. https://doi.org/10.3389/fphar.2024.1510976 Shen J., Qin H., Li K., Ding H., Chen X., Peng M., Jiang X., and Han Y., 2024, The Angelica polysaccharide: a review of phytochemistry, pharmacology and beneficial effects on systemic diseases, International Immunopharmacology, 133: 112025. https://doi.org/10.1016/j.intimp.2024.112025 Shen J., Zhang M., Zhang K., Qin Y., Liu M., Liang S., Chen D., and Peng M., 2022, Effect of Angelica polysaccharide on mouse myeloid-derived suppressor cells, Frontiers in Immunology, 13: 989230. https://doi.org/10.3389/fimmu.2022.989230 Sun N., Wang Z., Jiang H., Wang B., Du K., Huang C., Wang C., Yang T., Wang Y., Liu Y., and Wang L., 2024, Angelica sinensis polysaccharides promote extramedullary stress erythropoiesis via ameliorating splenic glycolysis and EPO/STAT5 signaling-regulated macrophages, Journal of Molecular Histology, 55(5): 661-673. https://doi.org/10.1007/s10735-024-10219-z Tian M., Li K., Liu R., Du J., Zou D., and Ma Y., 2021, Angelica polysaccharide attenuates LPS-induced inflammation response of primary dairy cow claw dermal cells via NF-κB and MAPK signaling pathways, BMC Veterinary Research, 17(1): 248. https://doi.org/10.1186/s12917-021-02952-4 Tian Y., Shen X., Hu T., Liang Z., Ding Y., Dai H., Liu X., Lu T., Yin F., Shu Y., Guo Z., Su L., and Li L., 2024, Structural analysis and blood-enriching effects comparison based on biological potency of Angelica sinensis polysaccharides, Frontiers in Pharmacology, 15: 1405342. https://doi.org/10.3389/fphar.2024.1405342 Wang J., Ge B., Li Z., Guan F., and Li F., 2016, Structural analysis and immunoregulation activity comparison of five polysaccharides from Angelica sinensis, Carbohydrate Polymers, 140: 6-12. https://doi.org/10.1016/j.carbpol.2015.12.050 Wang K., Wang J., Song M., Wang H., Xia N., and Zhang Y., 2020a, Angelica sinensis polysaccharide attenuates CCl4-induced liver fibrosis via the IL-22/STAT3 pathway, International Journal of Biological Macromolecules, 162: 273-283. https://doi.org/10.1016/j.ijbiomac.2020.06.166 Wang M. Z., He X., Yu Z., Wu H., and Yang T.H., 2020b, A nano drug delivery system based on Angelica sinensis polysaccharide for combination of chemotherapy and immunotherapy, Molecules, 25(13): 3096. https://doi.org/10.3390/molecules25133096

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