Medicinal Plant Research 2025, Vol.15, No.3, 129-141 http://hortherbpublisher.com/index.php/mpr 139 Im D.S., 2020, Pro-resolving effect of ginsenosides as an anti-inflammatory mechanism of Panax ginseng, Biomolecules, 10(3): 444. https://doi.org/10.3390/biom10030444 Jang W.Y., Hwang J.Y., and Cho J.Y., 2023, Ginsenosides from Panax ginseng as key modulators of NF-κB signaling are powerful anti-inflammatory and anticancer agents, International Journal of Molecular Sciences, 24(7): 6119. https://doi.org/10.3390/ijms24076119 Jeon J.H., Lee J., Park J.H., Lee C.H., Choi M.K., and Song I.S., 2021, Effect of lactic acid bacteria on the pharmacokinetics and metabolism of ginsenosides in mice, Pharmaceutics, 13(9): 1496. https://doi.org/10.3390/pharmaceutics13091496 Jiang M., Chi J., Qiao Y., Wang J., Zhang Z., Liu J., Sheng X., and Yuan L., 2025, Ginsenosides Rg1, Rb1 and rare ginsenosides: Promising candidate agents for Parkinson's disease and Alzheimer's disease and network pharmacology analysis, Pharmacological Research, 212: 107578. https://doi.org/10.1016/j.phrs.2025.107578 Jin Y., Nguyen T.L.L., Myung C.S., and Heo K.S., 2022, Ginsenoside Rh1 protects human endothelial cells against lipopolysaccharide-induced inflammatory injury through inhibiting TLR2/4-mediated STAT3, NF-κB, and ER stress signaling pathways, Life Sciences, 309: 120973. https://doi.org/10.2139/ssrn.4122052 Jin Y., Tangchang W., Kwon O.S., Lee J.Y., Heo K.S., and Son H.Y., 2023, Ginsenoside Rh1 ameliorates the asthma and allergic inflammation via inhibiting Akt, MAPK, and NF-κB signaling pathways in vitro and in vivo, Life Sciences, 321: 121607. https://doi.org/10.2139/ssrn.4333539 Kang H., Kim S., Lee J.Y., and Kim B., 2023, Inhibitory effects of ginsenoside compound K on lipopolysaccharide-stimulated inflammatory responses in macrophages by regulating sirtuin 1 and histone deacetylase 4, Nutrients, 15(7): 1626. https://doi.org/10.3390/nu15071626 Kim J.H., Kim D.H., Jo S., Cho M.J., Cho Y.R., Lee Y.J., and Byun S., 2022, Immunomodulatory functional foods and their molecular mechanisms, Experimental & Molecular Medicine, 54(1): 1-11. https://doi.org/10.1038/s12276-022-00724-0 Kim J.H., Yi Y.S., Kim M.Y., and Cho J.Y., 2017, Role of ginsenosides, the main active components of Panax ginseng, in inflammatory responses and diseases, Journal of Ginseng Research, 41(4): 435-443. https://doi.org/10.1016/j.jgr.2016.08.004 Kim S.J., Lee J., Choi W.S., Kim H.J., Kim M.Y., Kim S.C., and Kim H.S., 2021, Ginsenoside F1 attenuates eosinophilic inflammation in chronic rhinosinusitis by promoting NK cell function, Journal of Ginseng Research, 45(6): 695-705. https://doi.org/10.1016/j.jgr.2021.03.007 Lee J.H., Min D.S., Lee C.W., Song K.H., Kim Y.S., and Kim H.P., 2018, Ginsenosides from Korean Red Ginseng ameliorate lung inflammatory responses: inhibition of the MAPKs/NF-κB/c-Fos pathways, Journal of Ginseng Research, 42(4): 476-484. https://doi.org/10.1016/j.jgr.2017.05.005 Lee J.O., Yang Y., Tao Y., Yi Y.S., and Cho J.Y., 2022, Korean Red Ginseng saponin fraction exerts anti-inflammatory effects by targeting the NF-κB and AP-1 pathways, Journal of Ginseng Research, 46(3): 489-495. https://doi.org/10.1016/j.jgr.2022.02.004 Lee Y., Saba E., Irfan M., Kim M., Chan J., Jeon B., Choi S., and Rhee M., 2019, The anti-inflammatory and anti-nociceptive effects of Korean black ginseng, Phytomedicine, 54: 169-181. https://doi.org/10.1016/j.phymed.2018.09.186 Li J., Huang Q., Yao Y., Ji P., Mingyao E., Chen J., Zhang Z., Qi H., Liu J., Chen Z., Zhao D., Zhou L., and Li X., 2022, Biotransformation, pharmacokinetics, and pharmacological activities of ginsenoside Rd against multiple diseases, Frontiers in Pharmacology, 13: 909363. https://doi.org/10.3389/fphar.2022.909363 Li S., Yuan R., Fan Q., Zhang C., Han S., Li J., Xu Z., Sun K., Xu Q., Yao C., Yang S., and Gao H., 2023, Ginsenoside Rb1 exerts therapeutic effects on ulcerative colitis through regulating the Nrf2/PIP2/NLRP3 inflammasome signaling pathway, Journal of Functional Foods, 102: 105475. https://doi.org/10.1016/j.jff.2023.105475 Li T., Zhang Y., Dong R., Bi W., Wang S., Zeng K., and Han L., 2024, Identification and mechanistic exploration of key anti‐inflammatory molecules in American ginseng: Impacts on signal transducer and activator of transcription 3 STAT3 phosphorylation and macrophage polarization, Phytotherapy Research, 38(8): 4307-4320. https://doi.org/10.1002/ptr.8277 Long J., Liu X., Kang Z., Wang M., Zhao H., Huang J., Xiao Q., Liu D., and Zhong Y., 2022, Ginsenoside Rg1 ameliorated experimental colitis by regulating the balance of M1/M2 macrophage polarization and the homeostasis of intestinal flora, European Journal of Pharmacology, 917: 174742. https://doi.org/10.1016/j.ejphar.2022.174742 Lu S., Luo Y., Zhou P., Yang K., Sun G., and Sun X., 2019, Ginsenoside compound K protects human umbilical vein endothelial cells against oxidized low-density lipoprotein-induced injury via inhibition of nuclear factor-κB, p38, and JNK MAPK pathways, Journal of Ginseng Research, 43(1): 95-104. https://doi.org/10.1016/j.jgr.2017.09.004 Mohanan P., Subramaniyam S., Mathiyalagan R., and Yang D.C., 2018, Molecular signaling of ginsenosides Rb1, Rg1, and Rg3 and their mode of actions, Journal of Ginseng Research, 42(2): 123-132. https://doi.org/10.1016/j.jgr.2017.01.008
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