Medicinal Plant Research 2025, Vol.15, No.3, 129-141 http://hortherbpublisher.com/index.php/mpr 132 Figure 1 Effects of GS-Rg1 on inflammatory injury of periodontal tissue. (A) Chemical structure of GS-Rg1. (B) Inflammatory cell counts of the groups (n). (C) H&E staining was used to detect the periodontal histopathological changes. M1 = first molar; C = cementum; AB = alveolar bone; GE = gingival epithelium; and PL = periodontal ligament. (D)–(F) Representative images of Immunohistochemistry (IHC) detected the expression of IL-6 and TGF-β1 and statistical analysis of positive area. (G) and (I) qPCR quantification of the mRNA levels of IL-6 and TGF-β1 in different groups. * P < 0.05, reference Ctrl; # P < 0.05, reference PD; & P < 0.05, reference GS-Rg1 (Adopted from Zhou et al., 2025) Image caption: After Rg1 treatment, the number of inflammatory cells was markedly reduced, and epithelial integrity was restored. Immunohistochemistry and qPCR results further showed that IL-6 levels were significantly elevated and TGF-β1 was decreased in the model group, whereas the Rg1 group reversed this trend. Overall, the findings reveal that Rg1 can effectively alleviate local inflammatory responses and improve pathological damage in periodontal tissues (Adopted from Zhou et al., 2025)
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