MPR_2025v15n2

Medicinal Plant Research 2025, Vol.15, No.2, 88-98 http://hortherbpublisher.com/index.php/mpr 97 He J., Chen L., Chu B., and Zhang C., 2018, Determination of total polysaccharides and total flavonoids in Chrysanthemum morifoliumusing near-infrared hyperspectral imaging and multivariate analysis, Molecules, 23(9): 2395. https://doi.org/10.3390/molecules23092395 Hou X., Huang X., Li J., Jiang G., Shen G., Li S., Luo Q., Wu H., Li M., Liu X., Chen A., Ye M., and Zhang Z., 2020, Extraction optimization and evaluation of the antioxidant and α-glucosidase inhibitory activity of polysaccharides from Chrysanthemum morifoliumcv. Hangju, Antioxidants, 9(1): 59. https://doi.org/10.3390/antiox9010059 Huang Y., Feng Y., Tang G., Li M., Zhang T., Fillet M., Crommen J., and Jiang Z., 2017, Development and validation of a fast SFC method for the analysis of flavonoids in plant extracts, Journal of Pharmaceutical and Biomedical Analysis, 140: 384-391. https://doi.org/10.1016/j.jpba.2017.03.012 Huang Y., Tao M., Li R., Liang F., Xu T., Zhong Q., Yuan Y., Wu T., Pan S., and Xu X., 2023, Identification of key phenolic compounds for alleviating gouty inflammation in edible chrysanthemums based on spectrum-effect relationship analyses, Food Chemistry: X, 20: 100897. https://doi.org/10.1016/j.fochx.2023.100897 Khan J., Deb P. K., Priya S., Medina K. D., Devi R., Walode S. G., and Rudrapal M., 2021, Dietary flavonoids: Cardioprotective potential with antioxidant effects and their pharmacokinetic, toxicological and therapeutic concerns, Molecules, 26(13): 4021. https://doi.org/10.3390/molecules26134021 Liu X., Liu Y., Shan C., Yang X., Zhang Q., Xu N., Xu L., and Song W., 2022, Effects of five extraction methods on total content, composition, and stability of flavonoids in jujube, Food Chemistry: X, 14: 100287. https://doi.org/10.1016/j.fochx.2022.100287 Liu Y., Lu C., Zhou J., Zhou F., Gui A., Chu H., and Shao Q., 2024, Chrysanthemum morifoliumas a traditional herb: A review of historical development, classification, phytochemistry, pharmacology and application, Journal of Ethnopharmacology, 330: 118198. https://doi.org/10.1016/j.jep.2024.118198 Long W., Bai X., Wang S., Chen H., Yin X., Gu H., Yang J., and Fu H., 2022, UHPLC-QTOF-MS-based untargeted metabolomics and mineral element analysis insight into the geographical differences of Chrysanthemum morifoliumRamat cv. “Hangbaiju” from different origins, Food Research International, 163: 112186. https://doi.org/10.1016/j.foodres.2022.112186 Lu C., Yan X., Zhang H., Zhong T., Gui A., Liu Y., Pan L., and Shao Q., 2024, Integrated metabolomic and transcriptomic analysis reveals biosynthesis mechanism of flavone and caffeoylquinic acid in chrysanthemum, BMC Genomics, 25(1): 759. https://doi.org/10.1186/s12864-024-10676-6 Premathilaka R., Rashidinejad A., Golding M., and Singh J., 2022, Oral delivery of hydrophobic flavonoids and their incorporation into functional foods: Opportunities and challenges, Food Hydrocolloids, 128: 107567. https://doi.org/10.1016/j.foodhyd.2022.107567 Sarkar C., Chaudhary P., Jamaddar S., Janmeda P., Mondal M., Mubarak M. S., and Islam M. T., 2022, Redox activity of flavonoids: Impact on human health, therapeutics, and chemical safety, Chemical Research in Toxicology, 35(2): 140-162. https://doi.org/10.1021/acs.chemrestox.1c00348 Song G., Liu J., Shui R., Sun J., Weng Q., Qiu S., Wang D., Liu S., Xiao G., Chen X., Shen Q., Gong J., and Zheng F., 2022, Effect of steam explosion pretreatment on the composition and bioactive characteristic of phenolic compounds in Chrysanthemum morifoliumRamat cv. Hangbaiju powder with various sieve fractions, Food Science & Nutrition, 10(6): 1888-1898. https://doi.org/10.1002/fsn3.2805 Tang S., Wang B., Liu X., Xi W., Yue Y., Tan X., Bai J., and Huang L., 2024, Structural insights and biological activities of flavonoids: Implications for novel applications, Food Frontiers, 6(1): 218-247. https://doi.org/10.1002/fft2.494 Wang T., Zou Q., Guo Q., Yang F., Wu L., and Zhang W., 2019, Widely targeted metabolomics analysis reveals the effect of flooding stress on the synthesis of flavonoids in Chrysanthemum morifolium, Molecules, 24(20): 3695. https://doi.org/10.3390/molecules24203695 Wang W., Lin L., and Zhao M., 2024, Simultaneously efficient dissolution and structural modification of chrysanthemum pectin: Targeting at proliferation of Bacteroides, International Journal of Biological Macromolecules, 267: 131469. https://doi.org/10.1016/j.ijbiomac.2024.131469 Wang X., Ma Y., Xu Q., Shikov A.N., Pozharitskaya O.N., Flisyuk E.V., Liu M., Li H., Vargas-Murga L., and Duez P., 2022, Flavonoids and saponins: What have we got or missed?, Phytomedicine, 109: 154580. https://doi.org/10.1016/j.phymed.2022.154580 Wu T., Yu C., and Li R., 2017, Determination of flavonoids in Flos Chrysanthemi and Flos Chrysanthemi Indici by capillary electrophoresis, Instrumentation Science & Technology, 45(4): 412-422. https://doi.org/10.1080/10739149.2016.1258572 Yang M., Tian X., Zhang M., Wei J., Niu Y., Hou J., Jin Y., and Du Y., 2022, A holistic comparison of flavor signature and chemical profile in different harvesting periods of Chrysanthemum morifoliumRamat. based on metabolomics combined with bioinformatics and molecular docking strategy, RSC Advances, 12(54): 34971-34989. https://doi.org/10.1039/d2ra05698d

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