MPR_2025v15n1

Medicinal Plant Research 2025, Vol.15, No.1, 1-11 http://hortherbpublisher.com/index.php/mpr 11 Li L.X., Liu H.Y., Zhang Q.Y., Li Z.Y., Wong T.F., Fung H.K., Zhang J.R., Bai S.L., Lu A.P., and Han Q.J., 2018, Comprehensive comparison of polysaccharides from Ganoderma lucidumand G. sinense: Chemical, antitumor, immunomodulating and gut-microbiota modulatory properties, Scientific Reports, 8: 22885. https://doi.org/10.1038/s41598-018-22885-7 Li M.M., Yu L., Zhai Q.X., Chu C.L., Wang S.M., Zhao J.X., Zhang H., Tian F.W., and Chen W., 2023, Combined Ganoderma lucidumpolysaccharide and ciprofloxacin therapy alleviates Salmonella enterica infection, protects the intestinal barrier, and regulates gut microbiota, Food & Function. 14(8): 3685-3698. https://doi.org/10.1039/d3fo00625e Liu G.Y., Zhang J.X., Hou T.T., An S.Q., Guo B.L., Liu C.F., Hu L.P., Huang Y.B., Zhang S.L., Song M., and Cao Y.L., 2021, Extraction kinetics, physicochemical properties and immunomodulatory activity of the novel continuous phase transition extraction of polysaccharides from Ganoderma lucidum, Food & Function, 12(20): 9708-9718. https://doi.org/10.1039/d1fo02185k Lu J.Q., He R.L., Sun P.H., Zhang F.F., Linhardt R.J., and Zhang A.Q., 2020, Molecular mechanisms of bioactive polysaccharides from Ganoderma lucidum (Lingzhi): A review, International Journal of Biological Macromolecules. 150: 765-774. https://doi.org/10.1016/j.ijbiomac.2020.02.035 Luo J.Y., Zhang C.X., Liu R.R., Gao L., Ou S.Y., Liu L.L., and Peng X.C., 2018, Ganoderma lucidumpolysaccharide alleviating colorectal cancer by alteration of special gut bacteria and regulation of gene expression of colonic epithelial cells, Journal of Functional Foods. 47: 127-135. https://doi.org/10.1016/J.JFF.2018.05.041 Lv X.C., Guo W.J., Li L.H., Yu X.H., and Liu B.L., 2019, Polysaccharide peptides from Ganoderma lucidumameliorate lipid metabolic disorders and gut microbiota dysbiosis in high-fat diet-fed rats, Journal of Functional Foods. 57: 229-240. https://doi.org/10.1016/J.JFF.2019.03.043 Sang T.T., Guo C.Y., Guo D.L., Wu J.W., Wang Y.Y., Wang Y.L., Chen J.Q., Chen C.R., Wu K.L., Na K.Y., Li K.X., Fang L.J., Guo C.F., and Wang X.L., 2021, Suppression of obesity and inflammation by polysaccharide from sporoderm-broken spore of Ganoderma lucidumvia gut microbiota regulation, Carbohydrate Polymers, 256: 117594. https://doi.org/10.1016/j.carbpol.2020.117594 Su L.F., Li D.D., Su J.Y., Zhang E.H., Chen S.J., Zheng C.F., Luo T.T., Li M.M., Chen X.H., Huang G.Y., Xie Y.Y., and Li S.L., 2021, Polysaccharides of sporoderm-broken spore of Ganoderma lucidummodulate adaptive immune function via gut microbiota regulation, Evidence-Based Complementary and Alternative Medicine, 2021: 8842062. https://doi.org/10.1155/2021/8842062 Swallah M.K., Bondzie-Quaye P.A., Wu Y.H., Acheampong A., Sossah F.L., Elsherbiny S.M., and Huang Q.L., 2023, Therapeutic potential and nutritional significance of Ganoderma lucidum—A comprehensive review from 2010 to 2022, Food & Function. https://doi.org/10.1039/d2fo01683d Tong A.J., Hu R., Wu L.Y., Lv X.C., Li X.H., Zhao L.L., and Liu B.L., 2019, Ganoderma polysaccharide and chitosan synergistically ameliorate lipid metabolic disorders and modulate gut microbiota composition in high-fat diet-fed golden hamsters, Journal of Food Biochemistry, 43(11): e13109. https://doi.org/10.1111/jfbc.13109 Wachtel-Galor S., Yuen J., Buswell J.A., and Benzie I.F.F., 2011, Ganoderma lucidum(Lingzhi or Reishi): A medicinal mushroom, Herbal Medicine: Biomolecular and Clinical Aspects. 9: 175-200. https://doi.org/10.1201/B10787-15 Wu X.Y., Cao J.Y., Li M.M., Yao P.Y., Li H.Q., Xu W.J., Yuan C.Y., Liu J.X., Wang S.L., Li P.P., and Wang Y.H., 2020, An integrated microbiome and metabolomic analysis identifies immunoenhancing features of Ganoderma lucidumspores oil in mice, Pharmacological Research, 158: 104937. https://doi.org/10.1016/j.phrs.2020.104937 Yang L.Y., Kang X.H., Dong W.Y., Wang L.J., Liu S.B., Zhong X.H., and Liu D.L., 2022, Prebiotic properties of Ganoderma lucidumpolysaccharides with special enrichment of Bacteroides ovatusand B. uniformisin vitro, Journal of Functional Foods, 92: 105069. https://doi.org/10.1016/j.jff.2022.105069 Zheng M.H., Pi X.Q., Li H.Y., Cheng S.Q., Su Y., Zhang Y.L., Man C.Y., and Jiang Y.Y., 2022, Ganoderma spp.polysaccharides are potential prebiotics: A review, Critical Reviews in Food Science and Nutrition, 62(19): 5189-5207. https://doi.org/10.1080/10408398.2022.2110035

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