MPR_2024v14n6

Medicinal Plant Research 2024, Vol.14, No.6, 358-370 http://hortherbpublisher.com/index.php/mpr 368 Chaicharoenaudomrung N., Jaroonwitchawan T., and Noisa P., 2018, Cordycepin induces apoptotic cell death of human brain cancer through the modulation of autophagy, Toxicology in Vitro, 46: 113-121. https://doi.org/10.1016/j.tiv.2017.10.002 Chatnarin S., and Thirabunyanon M., 2023, Potential bioactivities via anticancer, antioxidant, and immunomodulatory properties of cultured mycelial enriched β-D-glucan polysaccharides from a novel fungus Ophiocordyceps sinensis OS8, Frontiers in Immunology, 14: 1150287. https://doi.org/10.3389/fimmu.2023.1150287 Chen J., Liang R.S., Zhuang B.B., Chen H.D., Liu S., Zhang G.L., and Shi S.S., 2024, Cordycepin inhibits glioma growth by downregulating PD-L1 expression via the NOD-like receptor/NFKB1/STAT1 axis, Chemico-Biological Interactions, 400: 111178. https://doi.org/10.1016/j.cbi.2024.111178 Cheong K.L., Wang L.Y., Wu D.T., Hu D.J., Zhao J., and Li S.P., 2016, Microwave-assisted extraction, chemical structures, and chain conformation of polysaccharides from a novel Cordyceps sinensis fungus UM01, Journal of Food Science, 81(9): C2167-C2174. https://doi.org/10.1111/1750-3841.13407 Cui L., Zhao L., Shen G., Yu D., Yuan T., Zhang Y., and Yang B., 2024, Antitumor mechanism and therapeutic potential of cordycepin derivatives, Molecules, 29(2): 483. https://doi.org/10.3390/molecules29020483 Cui Z., Park S., Jo E., Hwang I., Lee K., Kim S., Kim D., Joo J., Hong S., Lee M., and Jang I., 2018, Cordycepin induces apoptosis of human ovarian cancer cells by inhibiting CCL5-mediated Akt/NF-κB signaling pathway, Cell Death Discovery, 4(1): 62. https://doi.org/10.1038/s41420-018-0063-4 Dai K.Y., Liu C., Ji H.Y., and Liu A.J., 2024a, Extraction, structural identification and anti-tumor activity of two Cordyceps militaris polysaccharides evaluated by S180 tumor-bearing mice, Industrial Crops and Products, 210: 118163. https://doi.org/10.1016/j.indcrop.2024.118163 Dai K.Y., Wang R.H., Mu L., Ji H.Y., and Liu A.J., 2024b, Structural characteristics and anti-tumor activity of alcohol-precipitated polysaccharides from Cordyceps militaris under different ethanol concentrations, International Journal of Biological Macromolecules, 278: 134784. https://doi.org/10.1016/j.ijbiomac.2024.134784 Deng Q., Li X., Fang C., Li X., Zhang J., Xi Q., Li Y., and Zhang R., 2022, Cordycepin enhances anti-tumor immunity in colon cancer by inhibiting phagocytosis immune checkpoint CD47 expression, International Immunopharmacology, 107: 108695. https://doi.org/10.1016/j.intimp.2022.108695 Guan J., Han L., Shi N., Zhu H., and Wang J., 2020, Development, in vitro biocompatibility, and antitumor efficacy of acetic acid-modified Cordyceps sinensis polysaccharide nanoparticle drug delivery system, Brazilian Journal of Pharmaceutical Sciences, 56: e18470. https://doi.org/10.1590/s2175-97902019000418470 Gunter N., Ong Y., Lai Z., Morita H., Chamyuang S., Owatworakit A., and Mah S., 2025, Anti-cancer effects of Cordyceps sinensis, C. militaris and C. cicadae and their mechanisms of action, Journal of Asian Natural Products Research, pp.1-25. https://doi.org/10.1080/10286020.2025.2497282 He B.L., Zheng Q.W., Guo L.Q., Huang J.Y., Yun F., Huang S.S., and Lin J.F., 2020, Structural characterization and immune-enhancing activity of a novel high-molecular-weight polysaccharide fromCordyceps militaris, International Journal of Biological Macromolecules, 145: 11-20. https://doi.org/10.1016/j.ijbiomac.2019.12.115 Jing Y., Cui X., Chen Z., Huang L., Song L., Liu T., Lv W., and Yu R., 2014, Elucidation and biological activities of a new polysaccharide from cultured Cordyceps militaris, Carbohydrate Polymers, 102: 288-296. https://doi.org/10.1016/j.carbpol.2013.11.061 Jing Y., Zhu J., Liu T., Bi S., Hu X., Chen Z., Song L., Lv W., and Yu R., 2015, Structural characterization and biological activities of a novel polysaccharide from culturedCordyceps militaris and its sulfated derivative, Journal of Agricultural and Food Chemistry, 63(13): 3464-3471. https://doi.org/10.1021/jf505915t Jo E., Jang H., Yang K., Jang M., Huh Y., Yoo H., Park J., Jang I., and Park S., 2020, Cordyceps militaris induces apoptosis in ovarian cancer cells through TNF-α/TNFR1-mediated inhibition of NF-κB phosphorylation, BMC Complementary Medicine and Therapies, 20(1): 1. https://doi.org/10.1186/s12906-019-2780-5 Jędrejko K.J., Lazur J., and Muszyńska B., 2021, Cordyceps militaris: An overview of its chemical constituents in relation to biological activity, Foods, 10(11): 2634. https://doi.org/10.3390/foods10112634 Li F., Y. Y., Hua W., Liu Y., Li L., Lu Z., Jiang X., Liu C., and Liu J., 2022, Cordyceps militaris polysaccharide exerted anticancer effect via activating the endogenous apoptosis pathway, Pharmacognosy Magazine, 18(79): 669-674. https://doi.org/10.4103/pm.pm_585_21 Li W., Zhao B., Liu X., He Z., Xie L., and Qian Z., 2025, Purification, structural characterization, and in vitro immunomodulatory activity of a low-molecular-weight polysaccharide from cultivated Chinese Cordyceps, International Journal of Biological Macromolecules, 301: 140394. https://doi.org/10.1016/j.ijbiomac.2025.140394 Liao Y., Ling J., Zhang G., Liu F., Tao S., Han Z., Chen S., Chen Z., and Le H., 2015, Cordycepin induces cell cycle arrest and apoptosis by inducing DNA damage and up-regulation of p53 in leukemia cells, Cell Cycle, 14(5): 761-771. https://doi.org/10.1080/15384101.2014.1000097

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