Medicinal Plant Research 2024, Vol.14, No.6, 345-357 http://hortherbpublisher.com/index.php/mpr 354 In the future, breeding of Hangbaiju should focus on developing climate-resilient varieties that are resistant to multiple pests and diseases as well as drought and heat stresses. This will rely on the combination of advanced phenotyping platforms, high-throughput screening technologies, and predictive breeding models. Interdisciplinary collaboration between breeders, plant pathologists, entomologists, and farmers will also be the key to the successful development and application of new varieties adapted to green cultivation and sustainable production systems. Acknowledgments The authors sincerely thank Dr. Zhang for reviewing the manuscript and providing valuable suggestions, which contributed to its improvement. Additionally, heartfelt gratitude is extended to the two anonymous peer reviewers for their comprehensive evaluation of the manuscript. Conflict of Interest Disclosure The authors affirm that this research was conducted without any commercial or financial relationships that could be construed as a potential conflict of interest. Reference Ahmad S., Wei X., Sheng Z., Hu P., and Tang S., 2020, CRISPR/Cas9 for development of disease resistance in plants: recent progress, limitations and future prospects, Briefings in Functional Genomics, 19(1): 26-39. https://doi.org/10.1093/bfgp/elz041 An C., Sheng L., Du X., Wang Y., Zhang Y., Song A., Jiang J., Guan Z., Fang W., Chen F., and Chen S., 2019, Overexpression of CmMYB15 provides chrysanthemum resistance to aphids by regulating the biosynthesis of lignin, Horticulture Research, 6: 1-10. https://doi.org/10.1038/s41438-019-0166-y Bi W.L., Pan C., Liu J., and Wang Q.C., 2016, Greenhouse performance, genetic stability and biochemical compounds in Chrysanthemum morifolium‘Hangju’ plants regenerated from cryopreserved shoot tips, Acta Physiologiae Plantarum, 38(11): 268. https://doi.org/10.1007/s11738-016-2288-2 Burketova L., Trda L., Ott P.G., and Valentova O., 2015, Bio-based resistance inducers for sustainable plant protection against pathogens, Biotechnology Advances, 33(6): 994-1004. https://doi.org/10.1016/j.biotechadv.2015.01.004 Chadfield V.G., Hartley S.E., and Redeker K.R., 2022, Associational resistance through intercropping reduces yield losses to soil-borne pests and diseases, New Phytologist, 235(6): 2393-2405. https://doi.org/10.1111/nph.18302 Chen G., Qiao J., Zhao G., Zhang H., Shen Y., and Cheng W., 2018, Rice-straw biochar regulating effect on Chrysanthemum morifoliumRamat. cv. 'Hangbaiju', Agronomy Journal, 110(5): 1996-2003. https://doi.org/10.2134/AGRONJ2017.12.0710 Chen Q., Zhang X., Jin R., and Mao H., 2024, Establishment of a CRISPR/Cas9 gene-editing system for Chrysanthemum morifolium, Ornamental Plant Research, 4(1): 1-9. https://doi.org/10.48130/opr-0024-0012 Ding Y., Wang X., Wang D., Jiang L., Xie J., Wang T., Song L., and Zhao X., 2023, Identification of CmbHLH transcription factor family and excavation of CmbHLHs resistant to necrotrophic fungus Alternaria in chrysanthemum, Genes, 14(2): 275. https://doi.org/10.3390/genes14020275 Fu X., Su J., Yu K., Cai Y., Zhang F., Chen S., Fang W., Fadi C., and Guan Z., 2018, Genetic variation and association mapping of aphid (Macrosiphoniella sanbourni) resistance in chrysanthemum (Chrysanthemum morifoliumRamat.), Euphytica, 214(2): 21. https://doi.org/10.1007/s10681-017-2085-z Gong J., Chu B., Gong L., Fang Z., Zhang X., Qiu S., Wang J., Xiang Y., Xiao G., Yuan H., and Zheng F., 2019, Comparison of phenolic compounds and the antioxidant activities of fifteen Chrysanthemum morifoliumRamat cv. ‘Hangbaiju’ in China, Antioxidants, 8(8): 325. https://doi.org/10.3390/antiox8080325 Guo Q.H., Li D.X., Wang K.C., Xue Y.R., Zhou X.S., and Chen Z.X., 2014, Identification of Chrysanthemum morifolium‘Hangbaiju’ resistances to leaf spot by ISSR, In: Proceedings, pp. 184-188. Hao D.C., Song Y., Xiao P., Zhong Y., Wu P., and Xu L., 2022, The genus Chrysanthemum: phylogeny, biodiversity, phytometabolites, and chemodiversity, Frontiers in Plant Science, 13: 973197. https://doi.org/10.3389/fpls.2022.973197 Hodaei M., Rahimmalek M., and Arzani A., 2019, Genetic diversity of Iranian Chrysanthemum morifolium cultivars using morphological traits and sequence-related amplified polymorphism (SRAP) markers, Horticulture, Environment, and Biotechnology, 60(5): 753-765. https://doi.org/10.1007/s13580-019-00137-5
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