Medicinal Plant Research 2024, Vol.14, No.6, 320-333 http://hortherbpublisher.com/index.php/mpr 320 Research Report Open Access Industrial-Scale Cultivation of Ganoderma lucidum: Challenges and Technological Innovations Jianfeng Wu1, TingWu2, Jinrong Chen3, Haijuan Zhang4 1 Lishui Crop Research Institute, Lishui, 323000, Zhejiang, China 2 Longquan Xianzhitang Biological Technology Co., Ltd., Longquan, 323700, Zhejiang, China 3 Zhejiang Yuanjian Biopharmaceutical Co., Ltd., Longquan, 323700, Zhejiang, China 4 Longquan Agricultural and Rural Bureau, Longquan, 323700, Zhejiang, China Corresponding author: 305755091@qq.com Medicinal Plant Research, 2024, Vol.14, No.6 doi: 10.5376/mpr.2024.14.0027 Received: 08 Oct., 2024 Accepted: 13 Nov., 2024 Published: 28 Nov., 2024 Copyright © 2024 Wu et al., This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Preferred citation for this article: Wu J.F., Wu T., Chen J.R., and Zhang H.J., 2024, Industrial-scale cultivation of Ganoderma lucidum: challenges and technological innovations, Medicinal Plant Research, 14(6): 320-333 (doi: 10.5376/mpr.2024.14.0027) Abstract Ganoderma lucidumis highly valued for its rich bioactive compounds, offering a range of therapeutic effects, including immune enhancement, antioxidant, anti-inflammatory, etc. With the growing global demand for G. lucidumproducts, industrial-scale cultivation has become increasingly important. This study comprehensively explores the industrial-scale cultivation of G. lucidum, with a focus on analyzing its challenges and corresponding solutions. In response to key issues such as environmental control and contamination management in the cultivation process, innovative methods such as substrate optimization and the introduction of bioreactor technology are proposed to improve the production efficiency, product quality, and sustainability of G. lucidumcultivation. The study demonstrates that industrial-scale cultivation not only reduces costs and increases yield but also ensures the efficacy and quality standards of G. lucidumproducts. Continued development and promotion of large-scale cultivation techniques are crucial to meeting global market demand, while providing valuable reference and guidance for the application of G. lucidum in pharmaceuticals and health foods. Keywords Ganoderma lucidum; Large-scale cultivation; Technological innovation; Bioreactor; Substrate optimization; Sustainable strategies 1 Introduction Ganoderma lucidum, commonly known as Reishi or Lingzhi, is a medicinal mushroom highly valued for its bioactive compounds, which have been widely used in traditional medicine, particularly in East Asia (El Sheikha, 2022). This fungus has garnered significant global interest due to its numerous therapeutic properties, including immune enhancement, anti-inflammatory, antioxidant, and anti-tumor effects (Lu et al., 2020; Ahmad et al., 2021). As the demand for Ganoderma lucidum-based products continues to rise, efforts to optimize and expand its cultivation have become increasingly critical. The shift towards industrial-scale production is essential to meet global demand and enhance accessibility, thereby promoting further research and applications of this versatile mushroom. Ganoderma lucidum is traditionally cultivated using several methods, including log cultivation, sawdust bag cultivation, and submerged fermentation. Each method has its own advantages and challenges, which influence the yield, quality, and production cost of Ganoderma lucidum. Log cultivation, for instance, simulates natural growing conditions, allowing the mushroom to develop its full range of bioactive compounds; however, it requires a long growth cycle and extensive land resources (Geetha et al., 2012). In contrast, sawdust bag cultivation offers higher control over the growth environment, resulting in faster yields, but it requires significant labor and careful environmental management (Sudheer et al., 2018; Chanshorphea, 2019). Submerged fermentation, often used for extracting specific metabolites, provides a more consistent and efficient production, yet requires sophisticated equipment and expertise (Feng et al., 2021). As the industry grows, developing and adopting innovative cultivation techniques that balance cost-efficiency, quality, and scalability are of paramount importance.
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