Medicinal Plant Research 2024, Vol.14, No.5, 285-296 http://hortherbpublisher.com/index.php/mpr 294 9 Concluding Remarks The development of functional beverages based on Polygonatum extract has shown promising potential in the health food market, particularly for hyperglycemic patients. Research has highlighted the bioactive compounds present in Polygonatum species, which possess significant medicinal properties. These compounds have been structurally characterized and various extraction methods have been optimized to harness their full potential. The clinical trial studies on hyperglycemic patients have demonstrated that these functional beverages can effectively manage blood glucose levels, thereby reducing the risk of adverse clinical outcomes associated with hyperglycemia. The practical application of these findings lies in the formulation of health-promoting beverages that can be integrated into the daily diet of individuals at risk of or managing diabetes, offering a natural and accessible means of glycemic control. Despite the promising findings, there are several limitations and shortcomings in the current research on Polygonatum-based functional beverages. One major limitation is the variability in the bioactive compound content due to differences in species, growing conditions, and extraction methods. Additionally, the clinical trials conducted so far have been limited in scale and duration, which may not fully capture the long-term effects and safety of these beverages in diverse populations. There is also a lack of standardized guidelines for the dosage and administration of Polygonatumextracts, which can lead to inconsistent results and hinder the practical application of these findings in clinical settings. Future research should focus on addressing the limitations identified in current studies. This includes conducting large-scale, long-term clinical trials to establish the efficacy and safety of Polygonatum-based functional beverages in a broader population. Standardizing the extraction methods and developing guidelines for dosage and administration will also be crucial for ensuring consistent and reliable results. Additionally, exploring the synergistic effects of Polygonatum extracts with other bioactive compounds could enhance their therapeutic potential and lead to the development of more effective functional beverages. The integration of advanced technologies such as continuous glucose monitoring and insulin pump therapy in clinical trials could provide more precise data on the impact of these beverages on glycemic control. Overall, the future of Polygonatum-based functional beverages in the health food market looks promising, with the potential to offer natural, effective solutions for managing hyperglycemia and improving overall health. Acknowledgments The authors sincerely thank two anonymous peer reviewers for providing targeted revision suggestions for the manuscript. Conflict of Interest Disclosure The authors affirm that this research was conducted without any commercial or financial relationships that could be construed as a potential conflict of interest. Reference Chai Y., Luo J., and Bao Y., 2021, Effects of Polygonatum sibiricumsaponin on hyperglycemia, gut microbiota composition and metabolic profiles in type 2 diabetes mice, Biomedicine & Pharmacotherapy, 143: 112155. https://doi.org/10.1016/j.biopha.2021.112155 Chasquibol N., Alarcón R., Gonzales B.F., Sotelo A., Landoni L., Gallardo G., García B., and Pérez-Camino M.C., 2022, Design of functional powdered beverages containing co-microcapsules of Sacha Inchi P. huayllabambana oil and antioxidant extracts of Camu Camu and mango skins, Antioxidants, 11(8): 1420. https://doi.org/10.3390/antiox11081420 Chen Z., Luo J., Jia M., Chai Y., and Bao Y., 2022, Polygonatum sibiricum saponin exerts beneficial hypoglycemic effects in type 2 diabetes mice by improving hepatic insulin resistance and glycogen synthesis-related proteins, Nutrients, 14(24): 5222. https://doi.org/10.3390/nu14245222 Deng Y., He K., Ye X., Chen X., Huang J., Li X., Yuan L., Jin Y., Jin Q., and Li P., 2012, Saponin rich fractions fromPolygonatum odoratum(Mill.) Druce with more potential hypoglycemic effects, Journal of Ethnopharmacology, 141(1): 228-233. https://doi.org/10.1016/j.jep.2012.02.023
RkJQdWJsaXNoZXIy MjQ4ODYzNA==