Medicinal Plant Research 2024, Vol.14, No.5, 285-296 http://hortherbpublisher.com/index.php/mpr 292 managing T2DM (Chai et al., 2021). Additionally, the aqueous extract of Polygonatum sibiricum (PSAE) was well-tolerated in diabetic mice, with no adverse effects reported during the study period (Wang et al., 2022). Moreover, the structural characterization and hypoglycemic effects of PKPs-1 from P. kingianum were investigated, and the results indicated that PKPs-1 is composed mainly of glucose and mannose, which are generally considered safe for consumption (Li et al., 2021). These findings suggest that Polygonatum-based functional beverages are not only effective but also safe and well-tolerated for managing hyperglycemia and related metabolic disorders. 7 Product Optimization Strategies Based on Clinical Research 7.1 Improvement and optimization of product formulation and production processes The formulation and production processes of functional beverages based on Polygonatum extract can be significantly enhanced by adopting traditional processing methods such as the Nine Steaming Nine Sun-drying technique. This method has been shown to substantially improve the anti-oxidative, anti-inflammatory, and anti-hyperglycemic properties of P. kingianum extracts. Specifically, the processed extracts demonstrated enhanced bioactivity in cell models, which can be attributed to the increased concentration of key metabolites such as polyphenols, flavonoids, alkaloids, and organic acids. These findings suggest that incorporating traditional processing methods can optimize the health benefits of Polygonatum-based beverages, making them more effective for hyperglycemic patients (Zhou et al., 2023). Additionally, integrating advanced analytical techniques like foodomics and network pharmacology can further refine the production process. By identifying and enhancing specific bioactive compounds responsible for the health-promoting activities, manufacturers can tailor the formulation to maximize efficacy. For instance, molecular docking studies have confirmed the high affinity between key constituents of processed Polygonatum and their predicted targets, providing a scientific basis for the improved tonic effects observed. This approach not only enhances the product's therapeutic potential but also ensures consistency and quality in production (Zhou et al., 2023). 7.2 Strategies for enhancing bioactive components To enhance the bioactive components of Polygonatum-based functional beverages, research should focus on the synergistic effects of combining different bioactive compounds. Studies have shown that the health benefits of Polygonatum extracts can be significantly amplified when multiple bioactive compounds work together. For example, the combination of polyphenols, flavonoids, and alkaloids in processed Polygonatumextracts has been found to improve anti-hyperglycemic effects through the modulation of key metabolic pathways such as PI3K-Akt, MAPK, and HIF-1 (Zhou et al., 2023). Understanding these synergistic interactions can lead to the development of more potent formulations that offer enhanced therapeutic benefits. Moreover, exploring various extraction methods to isolate and concentrate these bioactive compounds can further enhance their efficacy. Advanced extraction techniques, such as supercritical fluid extraction and ultrasonic-assisted extraction, can be employed to obtain high-purity extracts with a higher concentration of active ingredients. These methods not only improve the yield of bioactive compounds but also preserve their structural integrity, ensuring maximum bioavailability and effectiveness in functional beverages (Li et al., 2021b). 7.3 Solutions to improve product taste and consumer acceptance Improving the taste and consumer acceptance of Polygonatum-based functional beverages is crucial for their success in the market. One effective strategy is to blend Polygonatumextracts with other natural ingredients that enhance flavor while maintaining the health benefits. For instance, combining Polygonatumwith fruits, herbs, or natural sweeteners can create a more palatable product without compromising its therapeutic properties. This approach can help mask any undesirable flavors associated with the raw extract, making the beverage more appealing to a broader audience (Li et al., 2021b).
RkJQdWJsaXNoZXIy MjQ4ODYzNA==