Medicinal Plant Research 2024, Vol.14, No.5, 285-296 http://hortherbpublisher.com/index.php/mpr 285 Research Perspective Open Access Development of Functional Beverages Based on Polygonatum Extract and Its Clinical Trial Study on Hyperglycemic Patients Zhichao Chen1, Haijuan Zhang2 1 Traditional Chinese Medicine Department, Longquan People's Hospital, Longquan, 323000, Zhejiang, China 2 Longquan Agricultural and Rural Bureau, Longquan, 323700, Zhejiang, China Corresponding author: 305755091@qq.com Medicinal Plant Research, 2024, Vol.14, No.5 doi: 10.5376/mpr.2024.14.0024 Received: 02 Sep., 2024 Accepted: 05 Oct., 2024 Published: 26 Oct., 2024 Copyright © 2024 Chen and Zhang, This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Preferred citation for this article: Chen Z.C., and Zhang H.J., 2024, Development of functional beverages based on Polygonatumextract and its clinical trial study on hyperglycemic patients, Medicinal Plant Research, 14(5): 285-296 (doi: 10.5376/mpr.2024.14.0024) Abstract Functional beverages based on Polygonatumextract have shown great development potential in the health food market, especially for hyperglycemic management. Polygonatum species are rich in various bioactive compounds with significant pharmacological effects, such as polysaccharides, saponins, and flavonoids, which are effective in lowering blood glucose, exhibiting antioxidant properties, and regulating metabolic health. Studies have demonstrated that Polygonatumextract can effectively control blood glucose levels by regulating glucose metabolism and improving insulin sensitivity. Additionally, Polygonatum-based functional beverages have shown positive effects on other health indicators, such as improving lipid profiles, reducing body weight, and alleviating inflammation. Despite the promising results, variations in the content of active compounds due to differences in species, cultivation conditions, and extraction methods pose challenges. Moreover, the limited scale and duration of current clinical trials suggest the need for standardized extraction processes, dosage guidelines, and large-scale, long-term clinical trials in future research. By optimizing formulations and production processes, Polygonatum-based functional beverages are expected to become a natural, safe, and effective health product, providing a new management approach for hyperglycemia and other metabolic disorders. Keywords Polygonatumextract; Functional beverage; Hyperglycemic management; Bioactive compounds; Clinical trials 1 Introduction Polygonatum, a genus within the Asparagaceae family, encompasses 71 species distributed across the temperate regions of the Northern Hemisphere. Traditionally, Polygonatumspecies have been utilized in various cultures, including China, India, Pakistan, Iran, and Japan, as medicinal tonics. These plants have demonstrated efficacy in treating a range of conditions such as age-related diseases, diabetes, lung diseases, fatigue, feebleness, and indigestion (Zhao et al., 2018). Recent research has highlighted the potential of Polygonatumspecies in modern medicine, particularly due to their rich composition of bioactive compounds like steroidal saponins, triterpenoid saponins, homoisoflavanones, polysaccharides, and lectins, which contribute to their pharmacological effects (Zhao et al., 2018). In Traditional Chinese Medicine (TCM), Polygonatum species, particularly P. sibiricum, P. kingianum, P. cyrtonema, and P. odoratum, are highly valued for their tonic properties. These species, known as "Huangjing" and "Yuzhu", have been used to enhance vitality and treat various ailments (Zhao et al., 2018). Modern scientific investigations have confirmed many of these traditional uses, demonstrating the anti-aging, anti-diabetic, anti-fatigue, and anticancer properties of Polygonatum extracts (Zhao et al., 2018). Furthermore, advanced processing techniques, such as the Nine Steaming Nine Sun-drying method, have been shown to enhance the anti-oxidative, anti-inflammatory, and anti-hyperglycemic effects of Polygonatum extracts, making them even more potent for therapeutic applications (Zhou et al., 2023). This study is to develop functional beverages based on Polygonatum extracts and to evaluate their efficacy in clinical trials involving hyperglycemic patients. Given the increasing prevalence of metabolic diseases, including diabetes, there is a critical need for effective and natural therapeutic options. This study aims to provide a scientifically validated, natural remedy that can be easily integrated into daily diets. The significance of this study
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