Medicinal Plant Research 2024, Vol.14, No.5, 245-258 http://hortherbpublisher.com/index.php/mpr 245 Research Report Open Access Natural Compounds fromEucommia ulmoides and Their Medicinal Properties DanZhao1, YiHuang2, Degang Zhao2,3 1 Guizhou Provincial People's Hospital, Guiyang, 550002, Guizhou, China 2 National-local Joint Engineering Research Center of Karst Region Plant Resources Utilization & Breeding (Guizhou), College of Life Sciences/Institute of Agro-Bioengineering, Guizhou University, Guiyang, 550025, Guizhou, China 3 Plant Conservation & Breeding Technology Center, Guizhou Key Laboratory of Agricultural Biotechnology/Biotechnology Institute of Guizhou Province, Guizhou Academy of Agricultural Sciences, Guiyang, 550006, Guizhou, China Corresponding author: dgzhao@gzu.edu.cn Medicinal Plant Research, 2024, Vol.14, No.5 doi: 10.5376/mpr.2024.14.0021 Received: 12 Aug., 2024 Accepted: 15 Sep., 2024 Published: 28 Sep., 2024 Copyright © 2024 Zhao et al., This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Preferred citation for this article: Zhao D., Huang Y., and Zhao D.G., 2024, Natural compounds fromEucommia ulmoides and their medicinal properties, Medicinal Plant Research, 14(5): 245-258 (doi: 10.5376/mpr.2024.14.0021) Abstract Eucommia ulmoides, a traditional medicinal plant, has been widely recognized for its therapeutic applications in Chinese medicine. This study focuses on analyzing the natural compounds found in Eucommia ulmoides and their medicinal properties and identifies the major phytochemical classes through various extraction and analytical techniques, followed by a quantitative and qualitative analysis. The pharmacological effects of these bioactive compounds were explored, with an emphasis on their antioxidant, anti-inflammatory, cardiovascular benefits,and immunomodulatory effects. Additionally, this study investigates biosynthetic pathways and genetic engineering approaches to enhance the production of beneficial compounds. Case studies are presented to demonstrate the therapeutic use of Eucommia ulmoides in hypertension, diabetic,arthritis, and neuroprotection. This study compares traditional applications with modern pharmacological advancements, addressing safety concerns, industrial applications, and market potential. The findings suggest that Eucommia ulmoides holds significant promise for future medicinal applications, offering a bridge between traditional knowledge and modern science. Keywords Eucommia ulmoides; Phytochemicals; Bioactive compounds; Medicinal properties; Pharmacological effects 1 Introduction Eucommia ulmoides Oliv., commonly known as Dù-zhòng in Chinese, is a unique species within the Eucommiaceae family (Xie et al., 2023). This plant has been a cornerstone of traditional Chinese medicine for nearly two millennia, with its leaves, bark, seeds, and flowers being utilized to treat a variety of ailments across China, Japan, and Korea (He et al., 2014). The plant is renowned for its therapeutic properties, which include antihypertensive, antihyperglycemic, and antioxidative effects, among others (Niu et al., 2016). The traditional use of E. ulmoides spans a wide range of applications, from treating hypertension and diabetes to enhancing sexual function ,improved gastrointestinal function and combating osteoporosis. Natural compounds have long been a focal point in medicinal research due to their diverse biological activities and potential therapeutic benefits. The phytochemical constituents of E. ulmoides, such as lignans, iridoids, flavonoids, and phenolics, have been extensively studied for their pharmacological properties (Zhu and Sun, 2018). These compounds exhibit a broad spectrum of bioactivities, including anti-inflammatory, antioxidant, and neuroprotective effects, making them valuable candidates for drug development and therapeutic applications (Wang et al., 2019). The exploration of these natural compounds not only enhances our understanding of traditional medicinal practices but also paves the way for the development of novel pharmaceuticals. This study systematically investigates the natural compounds present in E. ulmoides and evaluate their medicinal properties; isolates and identifies the bioactive constituents of E. ulmoides, assesses their pharmacological activities, and explores their potential applications in modern medicine. By providing a comprehensive analysis of the phytochemical and pharmacological profiles of E. ulmoides, this study seeks to bridge the gap between traditional knowledge and contemporary scientific research, ultimately contributing to the development of new therapeutic agents derived from natural sources.
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