Medicinal Plant Research 2024, Vol.14, No.5, 259-274 http://hortherbpublisher.com/index.php/mpr 259 Review Article Open Access Pharmacological Effects of Sanghuangporus spp. Extract and Its Application in the Prevention and Treatment of Chronic Diseases Haiyan Chen1,2 , Si Chen3, Jinge Zhang1, YanYang4, Yanran Wang1, Yaning Zhang1, HaijieXu1, Jiying Liu1, Dianda Zhang1 1 College of life sciences, Changchun Sci-Tech University, Changchun, 130600, Jilin, China 2 College of Pharmacy, Changchun University of Chinese Medicine, Changchun, 130117, Jilin, China 3 Yanbian Yida Birch Industry Co., Ltd., Changchun, 132000, Jilin, China 4 Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Fengxian, 201403, Shanghai, China Corresponding author: 100361@cstu.edu.cn Medicinal Plant Research, 2024, Vol.14, No.5 doi: 10.5376/mpr.2024.14.0022 Received: 20 Aug., 2024 Accepted: 28 Sep., 2024 Published: 12 Oct., 2024 Copyright © 2024 Chen et al., This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Preferred citation for this article: Chen H.Y., Chen S., Zhang J.G., Yang Y., Wang Y.R., Zhang Y.N., Xu H.J., Liu J.Y., and Zhang D.A. 2024, Pharmacological effects of Sanghuangporus spp. extract and its application in the prevention and treatment of chronic diseases, Medicinal Plant Research, 14(5): 259-274 (doi: 10.5376/mpr.2024.14.0022) Abstract Sanghuangporus spp., a traditional medicinal fungus, has garnered significant scientific attention due to its diverse pharmacological properties. This study systematically explores the bioactive components of Sanghuangporus spp., such as polysaccharides, triterpenoids, and flavonoids, and their mechanisms of action in preventing and treating various chronic diseases. Sanghuangporus spp. exhibits potent antioxidant, anti-tumor, anti-inflammatory, immunomodulatory, hepatoprotective, anti-diabetic, and cardiovascular protective effects. These characteristics make it a promising natural remedy for managing chronic conditions such as cancer, diabetes, liver disease, and cardiovascular disorders. However, challenges remain in standardizing Sanghuangporus spp. extracts, ensuring quality consistency, and translating preclinical findings into clinical practice. Future research should focus on large-scale clinical trials to elucidate the molecular mechanisms of its bioactive compounds and overcome regulatory barriers to integrate Sanghuangporus spp. into modern therapeutic strategies. This study evaluates the safety and efficacy of Sanghuangporus spp. extract, providing theoretical and practical references for its development into functional foods and pharmaceuticals. Keywords Sanghuangporus spp.; Pharmacological effects; Chronic diseases; Antioxidant; Anti-tumor 1 Introduction Sanghuangporus spp., commonly known as Sanghuang, is a traditional medicinal fungus widely used in Chinese medicine for its therapeutic properties. Historically, Sanghuangporus has been utilized to treat various ailments, including gastrointestinal disorders, liver diseases, and cancer. Recent studies have revealed that Sanghuangporus contains multiple bioactive compounds such as polysaccharides, triterpenoids, phenolics, and flavonoids, which contribute to its pharmacological activities (Zhang et al., 2022). Research has shown that these compounds exhibit anti-tumor, anti-inflammatory, antioxidant, antiviral, hypoglycemic, immunomodulatory, and hepatoprotective effects (Dong et al., 2019; Yang et al., 2021). Due to its broad spectrum of bioactivities, Sanghuangporus has attracted interest as a potential natural remedy for managing chronic diseases, including cancer, diabetes, cardiovascular diseases, and liver disorders (Dong et al., 2020; Wang et al., 2023). Chronic diseases, including cancer, diabetes, and cardiovascular disorders, are leading causes of morbidity and mortality worldwide (Shelton et al., 2022). Traditional therapeutic approaches often involve synthetic drugs, which may have significant side effects and limitations in long-term efficacy. In recent years, there has been a growing interest in natural products, including medicinal fungus like Sanghuangporus, due to their broad spectrum of biological activities and relatively low toxicity (Dong et al., 2024). Studies have shown that Sanghuangporus possesses various pharmacological properties, including antioxidant, anti-inflammatory, antiviral, antitumor, and immunomodulatory effects (Jiang et al., 2018). Pharmacological research on natural extracts like Sanghuangporus not only provides scientific validation for traditional medicine practices but also offers insights into developing novel therapeutic agents for chronic diseases with fewer adverse effects (Zhou et al., 2022b).
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