Medicinal Plant Research 2024, Vol.14, No.5, 245-258 http://hortherbpublisher.com/index.php/mpr 256 Moreover, the antidepressant potential of chlorogenic acid-enriched extracts from E. ulmoides bark, which promote serotonin release and neuron protection, highlights the plant's potential in developing natural antidepressant drugs (Wu et al., 2016). The unique properties of E. ulmoides rubber (EUR), a natural polymer with applications in environmental, agricultural, and biomedical engineering, also open new avenues for research and industrial use (Wei et al., 2021). In conclusion, the commercial extraction and production of E. ulmoides compounds, coupled with the growing market demand and economic impact, underscore the plant's significant industrial applications. The future prospects for pharmaceutical applications are vast, with ongoing research likely to uncover new therapeutic uses and enhance the commercial viability of this traditional medicinal plant. 9 Concluding Remarks Eucommia ulmoides, a traditional Chinese medicinal plant, has been extensively studied for its diverse pharmacological properties. The plant contains a wide array of bioactive compounds, including lignans, iridoids, flavonoids, phenols, steroids, and terpenes, which contribute to its medicinal efficacy. These compounds exhibit a range of therapeutic activities such as antihypertensive, antihyperglycemic, antihyperlipidemic, antioxidant, anti-osteoporotic, antitumor, immunomodulatory, and neuroprotective effects. Specific compounds like chlorogenic acid have shown potential in neuroprotection and antidepressant activities by promoting serotonin release and enhancing synapsin I expression. Additionally, iridoid glycosides from the seeds and male flowers of E. ulmoides have demonstrated significant antioxidant and anti-aging properties. The pharmacological potential of E. ulmoides suggests several promising avenues for future medicinal applications. The neuroprotective and antidepressant properties of chlorogenic acid-enriched extracts highlight the potential for developing treatments for neurological disorders and depression. The anti-inflammatory and antioxidant activities of iridoid glycosides suggest their use in managing chronic inflammatory conditions and oxidative stress-related diseases. Furthermore, the estrogenic properties of certain compounds in E. ulmoides indicate potential applications in hormone replacement therapy and the management of menopausal symptoms. Future research should focus on clinical trials to validate these effects in humans and explore the safety and efficacy of E. ulmoides-derived compounds in various therapeutic contexts. E. ulmoides has a long history of use in traditional Chinese medicine, and modern research has validated many of its traditional uses while uncovering new therapeutic potentials. The plant's diverse bioactive compounds and their wide-ranging pharmacological activities make it a valuable resource for developing new medicinal products. As research progresses, it is crucial to conduct comprehensive clinical studies to establish standardized dosages, safety profiles, and mechanisms of action. The integration of E. ulmoides into modern medicine could provide natural and effective treatments for a variety of health conditions, reinforcing its role as a significant medicinal plant. Funding This research was funded by a grant from the National Natural Science Foundation of China [No. 31360272], Guizhou Academy of Agricultural Sciences Talent Special Project (No. 2023-02 and No. 2024-02), National High Technology Research and Development Program of China (“863” Program) [grant number 2013AA102605-05], Talent Base for Germplasm Resources Utilization and Innovation of Characteristic Plant in Guizhou (RCJD2018-14). Acknowledgments We would like to express heartfelt gratitude to Ms. Xuan for reviewing the draft of this paper and providing valuable suggestions for improvement, which made the structure and content of the paper clearer and more rigorous. We would also like to thank the two anonymous peer reviewers for their professional reviews and insightful comments, which have helped further enhance the quality and academic rigor of this paper. Conflict of Interest Disclosure The authors affirm that this research was conducted without any commercial or financial relationships that could be construed as a potential conflict of interest.
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