Medicinal Plant Research 2024, Vol.14, No.5, 245-258 http://hortherbpublisher.com/index.php/mpr 252 Figure 7 EU70 decreases pro-inflammatory cytokine levels and the number of T cells (Th17-positive cells) and increases anti-inflammatory cytokine levels (IL-10). (A) IHC of TNFα and IL-1β in rat hind limb joints on day 49 (after 4 weeks of drug treatment) (×40). (B). Average optical density of IHC sections from the four groups. (C) Splenocytes were isolated from the rats on day 35 and day 49. Th17-positive cells were stained with a FITC-conjugated Th17 antibody and detected by flow cytometry. (D) Serum IL-10, IL-17, IL-1β and TNFα levels were detected by ELISA. The rats were treated with the different drugs on day 35 and day 49 after model generation. *: P<0.05 compared with the normal group; #: P<0.05 compared with the CIA group (Adopted from Wang et al., 2016)
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