Medicinal Plant Research 2024, Vol.14, No.3, 126-136 http://hortherbpublisher.com/index.php/mpr 131 Figure 2 DOX-induced cardiac dysfunction was inhibited by CME (Adopted from Ono et al., 2022) Image caption: (A) Representative photographs of M-mode images. (B) FS, fractional shortening. (C) EF, ejection fraction. (D) BW, body weight. (E) HW, heart weight; TL, tibia length. Values are presented as the mean SEM of 10 individual measurements (Adopted from Ono et al., 2022) 5.4 Neuroprotective and cognitive enhancing effects Chrysanthemum morifoliumhas shown promise in neuroprotection and cognitive enhancement. The flower extract was found to protect human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity, a model for Parkinson's disease, by reducing oxidative stress andapoptosis (Kim et al., 2009). Chrysanthemum extract improves mitochondrial function and increases the expression of genes related to mitochondrial biosynthesis in muscle tissue, which can alleviate neurodegenerative diseases (Lee et al., 2021). 5.5 Anticancer potential The anticancer potential of Chrysanthemum morifoliumis supported by its cytotoxic effects on various cancer cell lines. Acetone extracts from the flower demonstrated significant cytotoxicity against breast cancer (MCF-7), lung cancer (A549), and hepatocellular carcinoma (HepG2) cell lines, highlighting its potential as a source of bioactive compounds for cancertreatment (Sayed, 2023). Chrysanthemum extract has an active site that inhibits osteoclast
RkJQdWJsaXNoZXIy MjQ4ODYzNA==