MPR_2024v14n3

Medicinal Plant Research 2024, Vol.14, No.3, 171-179 http://hortherbpublisher.com/index.php/mpr 174 although less studied, also contribute to the anti-inflammatory and antioxidant properties of ginger (Unuofin et al., 2021; Abdalla et al., 2023). These compounds collectively make ginger tea a beneficial beverage for managing inflammation, oxidative stress, and various chronic diseases. 5.2 Phytochemical analysis and identification techniques The identification and analysis of bioactive compounds in ginger tea involve several advanced phytochemical techniques. High-performance liquid chromatography (HPLC) is commonly used to quantify gingerols, shogaols, and other phenolic compounds (Tavares et al., 2022). Gas chromatography-mass spectrometry (GC-MS) is another technique employed to analyze volatile compounds and essential oils in ginger (Lashgari et al., 2021). Additionally, nuclear magnetic resonance (NMR) spectroscopy provides detailed structural information about the bioactive molecules. These techniques ensure accurate identification and quantification of the bioactive compounds, facilitating the understanding of their health benefits and mechanisms of action. 5.3 Variations in bioactive compound content based on preparation The content of bioactive compounds in ginger tea can vary significantly based on its preparation method. Fresh ginger typically contains higher levels of gingerols, while dried ginger has increased concentrations of shogaols due to the dehydration process. Boiling ginger in water to make tea can lead to the extraction of water-soluble compounds like gingerols and Zingerone, but prolonged heating may convert gingerols to shogaols, altering the tea's bioactive profile (Figure 1) (Tavares et al., 2022; Velayati et al., 2023). Additionally, the particle size of ginger and the duration of steeping can influence the concentration of these compounds in the final beverage. Understanding these variations is crucial for optimizing the preparation of ginger tea to maximize its health benefits. Figure 1 The potential mechanism for the antioxidant action of 6-shogoal (Adopted from Mao et al., 2019) Image caption: 6-shogoal leads to the translocation of Nrf2 into the nucleus and increases the expression of Nrf2 target genes by modifying Keap1 and preventing Nrf2 from proteasomal degradation. Thus, the level of GSH increases, and the level of ROS decreases (Adopted from Mao et al., 2019) 6 Case Study: Ginger Tea in Clinical Practice 6.1 Application of ginger tea in managing inflammatory conditions Ginger tea has been widely recognized for its potent anti-inflammatory properties, which are attributed to its bioactive compounds such as gingerols and shogaols. These compounds have been shown to inhibit key inflammatory pathways, including the nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) pathways, as well as reducing the production of pro-inflammatory cytokines (Lashgari et al., 2021; Ballester et al., 2022). Clinical studies have demonstrated that ginger can significantly alleviate symptoms in patients with inflammatory diseases such as rheumatoid arthritis and ulcerative colitis, making it a valuable

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