Medicinal Plant Research 2024, Vol.14, No.3, 162-170 http://hortherbpublisher.com/index.php/mpr 162 Systematic Review Open Access Phytochemical Properties and Therapeutic Potential of Hydrocotyle vulgaris: A Systematic Review Jianli Lu1, FanWang2 1 Traditional Chinese Medicine Research Center, Cuixi Academy of Biotechnology, Zhuji, 311800, Zhejiang, China 2 Aquatic Biology Research Center, Cuixi Academy of Biotechnology, Zhuji, 311800, Zhejiang, China Corresponding author: fan.wang@cuixi.org Medicinal Plant Research, 2024, Vol.14, No.3 doi: 10.5376/mpr.2024.14.0014 Received: 29 Apr., 2024 Accepted: 02 Jun., 2024 Published: 21 Jun., 2024 Copyright © 2024 Lu and Wang, This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Preferred citation for this article: Lu J.L., and Wang F., 2024, Phytochemical properties and therapeutic potential of Hydrocotyle vulgaris: a systematic review, Medicinal Plant Research, 14(3): 162-170 (doi: 10.5376/mpr.2024.14.0014) Abstract Hydrocotyle vulgaris has been widely used in various folk remedies, and its rich phytochemical constituents, such as flavonoids, alkaloids, and tannins, have attracted the attention of modern scientific research. This study provides a comprehensive analysis of the phytochemical composition of Hydrocotyle vulgaris and its antioxidant, anti-inflammatory, antimicrobial, antiviral, neuroprotective, and cardiovascular health benefits through a systematic review of the existing literature. Various analytical methods, such as UV-visible spectroscopy and high-performance liquid chromatography (HPLC), were evaluated, along with the quantitative analysis of its vitamin content. Additionally, this study delves into how Hydrocotyle vulgaris influences cellular metabolism by modulating signaling pathways and gene expression, as well as its role in regulating oxidative stress, immune system function, and inflammatory pathways. Although current research has highlighted its therapeutic potential, more data on its long-term safety and toxicity are required. This study provides a theoretical foundation for the further development and application of Hydrocotyle vulgaris, while also exploring its potential in modern drug development through the integration of herbal medicine. Keywords Hydrocotyle vulgaris; Phytochemical composition; Antioxidant properties; Signal pathway modulation; Safety 1 Introduction Hydrocotyle vulgaris is a perennial herbaceous plant belonging to the family Araliaceae. This plant has been traditionally utilized in various medicinal systems across different cultures. For instance, in Ayurveda, it is known as 'Mandukaparni' and is used to treat ailments such as indigestion, dysentery, and nervous disorders. The plant is also recognized for its neuroprotective properties and has been used as a brain tonic in traditional medicine. Additionally, Hydrocotyle vulgaris has been employed by various ethnic communities to treat conditions like gastritis, throat infections, and jaundice (Mandal et al., 2020; Rosli et al., 2022). The study of the phytochemical properties and therapeutic potential of Hydrocotyle vulgaris is crucial for several reasons. Firstly, the plant contains a variety of bioactive compounds, including triterpenoids, flavonoids, and essential oils, which have demonstrated significant pharmacological activities such as antioxidant, antibacterial, and hepatoprotective effects (Ekiert et al., 2020; Ganie et al., 2022). Understanding these properties can lead to the development of new therapeutic agents and enhance the efficacy of existing treatments. Moreover, the plant's traditional uses in treating a wide range of ailments highlight its potential as a source of natural remedies (Hazarika et al., 2020; Kour et al., 2021). Given the increasing interest in natural and alternative medicine, a comprehensive study of Hydrocotyle vulgaris can provide valuable insights into its medicinal benefits and applications. This study systematically analyzes the existing literature on the phytochemical properties and therapeutic potential of Hydrocotyle vulgaris, identifying its active compounds and evaluating their pharmacological activities. It documents and analyzes the traditional uses of Hydrocotyle vulgaris, integrating these uses with scientific findings to verify its medicinal value. This research provides a comprehensive understanding of Hydrocotyle vulgaris, serving as a foundation for future studies and potential clinical applications, while also highlighting gaps
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