Medicinal Plant Research 2024, Vol.14, No.3, 137-150 http://hortherbpublisher.com/index.php/mpr 148 diseases and other related conditions. Furthermore, the impact of different processing methods on the efficacy of A. macrocephalashould be studied to standardize its use in health products. The transition of A. macrocephala from a traditional herb to a modern health product marks a significant milestone in the integration of traditional and modern medicine. The extensive pharmacological activities and therapeutic potential of A. macrocephala validate its traditional uses and highlight its importance in contemporary health care. As research continues to uncover the complex interactions and benefits of its bioactive compounds, A. macrocephala is poised to become a cornerstone in the development of new, effective health products. The ongoing health revolution of A. macrocephala underscores the value of traditional medicinal knowledge and its potential to contribute to modern medical advancements. Acknowledgments I would like to thank to MS White for her critically reading the manuscript and providing valuable feedback that improved the clarity of the text. I also sincerely appreciates the valuable opinions and suggestions provided by the two anonymous reviewers. Conflict of Interest Disclosure The author affirms that this research was conducted without any commercial or financial relationships that could be construed as a potential conflict of interest. References Bailly C., 2021, Atractylenolides, essential components of Atractylodes-based traditional herbal medicines: Antioxidant, anti-inflammatory and anticancer properties, European Journal of Pharmacology, 891: 173735. https://doi.org/10.1016/j.ejphar.2020.173735 Cai H., Chen C., Wang Y., and Wang H., 2020, The complete plastome sequence of Atractylodes macrocephala (Asteraceae: Cardueae), an important medicinal plant in East Asia, Mitochondrial DNA Part B, 5(1): 951-952. https://doi.org/10.1080/23802359.2020.1719926 Chan K.W.K., Chung H.Y., and Ho W.S., 2020, Anti-tumor activity of atractylenolide I in human colon adenocarcinoma in vitro, Molecules, 25(1): 212. https://doi.org/10.3390/molecules25010212 Chen C., Zheng L., Ma Q., Zhou W.B., Lu Y., Zhao Y.P., and Fu C.X., 2019, Impacts of domestication on population genetics of a traditional Chinese medicinal herb, Atractylodes macrocephala (Asteraceae), Journal of Systematics and Evolution, 57(3): 222-233. https://doi.org/10.1111/jse.12446 Chen S., Pang J., Chen T., Guan L., and Tang X., 2018, Meta analysis on clinical curative effect of reuse of Atractylodes macrocephala in treating chronic constipation, 7(2): 150-155. https://doi.org/10.3877/CMA.J.ISSN.2095-3224.2018.02.010 Cheng H., Zhang D., Wu J., Liu J., Tan Y., Feng W., and Peng C., 2023, Atractylodes macrocephala Koidz. volatile oil relieves acute ulcerative colitis via regulating gut microbiota and gut microbiota metabolism, Frontiers in Immunology, 14: 1127785. https://doi.org/10.3389/fimmu.2023.1127785 Cheng M., Min X., Yu X., and Zhao Z., 2023, Bioinformatics study of active substances and disease targets of Atractylodes macrocephala based on network pharmacology, International Journal of Frontiers in Medicine, 5(9). https://doi.org/10.25236/ijfm.2023.050911 Choi N.R., Choi W.G., Zhu A., Park J., Kim Y.T., Hong J., and Kim B.J., 2024, Exploring the therapeutic effects of Atractylodes macrocephala Koidz against human gastric cancer, Nutrients, 16(7): 965. https://doi.org/10.3390/nu16070965 Feng W., Liu J., Tan Y., Ao H., Wang J., and Peng C., 2020, Polysaccharides from Atractylodes macrocephala Koidz. ameliorate ulcerative colitis via extensive modification of gut microbiota and host metabolism, Food Research International, 138: 109777. https://doi.org/10.1016/j.foodres.2020.109777 Feng Y.Y., Ji H.Y., Dong X.D., Yu J., and Liu A.J., 2019, Polysaccharide extracted from Atractylodes macrocephala Koidz (PAMK) induce apoptosis in transplanted H22 cells in mice, International Journal of Biological Macromolecules, 137: 604-611. https://doi.org/10.1016/j.ijbiomac.2019.06.059 Gu S., Li L., Huang H., Wang B., and Zhang T., 2019, Antitumor, antiviral, and anti-inflammatory efficacy of essential oils fromAtractylodes macrocephala Koidz. produced with different processing methods, Molecules, 24(16): 2956. https://doi.org/10.3390/molecules24162956 Hu L., Chen X., Yang J., and Guo L., 2019, Geographic authentication of the traditional Chinese medicine Atractylodes macrocephala Koidz. (Baizhu) using stable isotope and multielement analyses, Rapid Communications in Mass Spectrometry, 33(22): 1703-1710. https://doi.org/10.1002/rcm.8519
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