Medicinal Plant Research 2024, Vol.14, No.3, 137-150 http://hortherbpublisher.com/index.php/mpr 145 Over 79 chemical compounds have been identified in A. macrocephala, including sesquiterpenoids, triterpenoids, and polysaccharides, which contribute to its diverse pharmacological effects such as anti-tumor, anti-inflammatory, and neuroprotective activities (Zhu et al., 2018). This scientific validation has paved the way for the development of modern applications, ensuring that the therapeutic benefits of A. macrocephala are accessible in more convenient and standardized forms. 6.2 Innovation in product formulations The versatility of Atractylodes macrocephala has spurred innovation in its product formulations. Today, it is available in various forms, such as dietary supplements, teas, and herbal extracts. Supplements typically include capsules or tablets standardized to contain specific concentrations of active compounds. Polysaccharide extracts from A. macrocephala have shown significant potential in promoting intestinal health by stimulating the migration of intestinal epithelial cells, which is crucial for healing intestinal injuries (Zeng et al., 2018). Herbal teas incorporating Atractylodes macrocephala are marketed for their digestive and calming properties, leveraging the herb’s traditional uses. Extracts, available as tinctures or powders, offer concentrated doses of the active ingredients and are often included in formulations for their convenience and efficacy. These innovative products ensure that the beneficial properties of Atractylodes macrocephala are accessible to a broader audience in forms that fit modern lifestyles (Gu et al., 2019; Lv et al., 2021). Additionally, the essential oils of A. macrocephala, when combined with other traditional herbs like Panax ginseng, have demonstrated efficacy in ameliorating chemotherapy-induced diarrhea by modulating gut microbiota (Wang et al., 2019). These findings have encouraged the development of new formulations that maximize the synergistic effects of A. macrocephala's bioactive compounds. 6.3 Integration into functional foods and beverages In addition to supplements and extracts, Atractylodes macrocephala has been integrated into functional foods and beverages, enhancing their nutritional and therapeutic value. Functional foods, such as fortified cereals and snack bars, incorporate Atractylodes macrocephala to leverage its immune-boosting and anti-inflammatory properties. These products are designed to offer health benefits beyond basic nutrition, making them an attractive option for health-conscious consumers (Feng et al., 2020; Jin et al., 2021). Beverages, including herbal teas and health drinks, utilize Atractylodes macrocephala for its calming and digestive benefits. These products are often marketed as wellness beverages, aimed at reducing stress, improving digestion, and enhancing overall well-being. The inclusion of Atractylodes macrocephala in these functional foods and beverages not only diversifies its applications but also ensures its continued relevance in modern health practices (Chan et al., 2020; Yang et al., 2022). The successful transition of Atractylodes macrocephala from a traditional herb to a modern health product highlights the synergy between ancient wisdom and contemporary science, ensuring its place in the future of health and wellness. 7 Clinical Applications and Research 7.1 Summary of clinical studies Atractylodes macrocephala, a traditional Chinese medicinal herb, has been extensively studied for its therapeutic potential in various clinical settings. Numerous clinical studies have demonstrated its benefits in treating gastrointestinal disorders, inflammatory conditions, and metabolic diseases. For instance, a meta-analysis evaluated the effectiveness of Atractylodes macrocephala in treating chronic constipation and found it significantly superior to other treatments, highlighting its safety and efficacy (Chen et al., 2018). Studies have shown that Atractylodes macrocephala possesses anti-hyperuricemia and anti-inflammatory properties, effectively reducing serum uric acid levels and inflammation in rat models of gouty arthritis (Qian et al., 2022). Additionally, bioinformatics and network pharmacology studies have identified key active substances and target genes, further elucidating its role in treating digestive tract diseases and various tumors (Cheng et al., 2023).
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