Medicinal Plant Research 2024, Vol.14, No.3, 126-136 http://hortherbpublisher.com/index.php/mpr 134 9 Concluding Remarks Chrysanthemum morifolium, a traditional Chinese medicinal herb, has demonstrated significant potential in modern scientific research for its diverse therapeutic properties. Chrysanthemum is rich in bioactive compounds such as flavonoids and volatile oils, giving it a rich pharmacological activity. Research has shown that chrysanthemum extract (CE) can enhance muscle mitochondrial content and activate the AMPK/SIRT1 pathway, improving inflammation caused by obesity. Chrysanthemum has traditionally been shown to have therapeutic effects on respiratory and cardiovascular diseases in medical history. Modern medical research has shown that chrysanthemum has antibacterial, anti-inflammatory, anticancer, and neuroprotective effects. Unlike wild chrysanthemums, chrysanthemums have unique chemical components and therapeutic properties, mainly reflected in the treatment of hypertension and metabolic disorders. Chrysanthemum leaf extract exhibits anti obesity effects by regulating lipid metabolism and reducing lipid toxicity intermediates. The new bioactive compounds isolated from chrysanthemum extract exhibit neuroprotective effects, further expanding their medicinal applications. The findings from these studies underscore the importance of Chrysanthemum morifoliumin both traditional and modern medicine. Future research should focus on elucidating the precise molecular mechanisms underlying its therapeutic effects, especially in the mechanisms of metabolism and inflammatory diseases. Investigating the synergistic effects of Chrysanthemum morifolium with other medicinal herbs could lead to the development of novel combination therapies. The bioactive compounds identified from chrysanthemums will enhance our understanding of their pharmacological effects. Clinical trials are necessary to validate the efficacy and safety of Chrysanthemum morifolium-based treatments in humans. The integration of traditional knowledge with modern scientific approaches will pave the way for innovative applications of Chrysanthemum morifoliumin healthcare and beyond. Chrysanthemum morifoliumrepresents a remarkable fusion of traditional Chinese medicine and modern scientific research. Its diverse bioactive compounds and therapeutic properties make it a valuable resource for addressing various health challenges. The convergence of traditional wisdom and contemporary science has not only validated the historical uses of Chrysanthemum morifoliumbut also uncovered new dimensions of its medicinal potential. As research progresses, Chrysanthemum morifolium is poised to play a significant role in the development of natural, effective, and sustainable therapeutic solutions. The journey of Chrysanthemum morifolium from ancient herbal remedies to modern medical marvels exemplifies the enduring relevance of traditional medicine in the quest for holistic health and well-being. Acknowledgments We are grateful to Dr. Fang for his critically reading the manuscript and providing valuable feedback that improved the clarity of the text. We also sincerely appreciate the valuable opinions and suggestions provided by the two anonymous reviewers. Funding This work was supported by China Agriculture Research System of MOF and MARA (CARS-21); Key Research and Development Program of Henan (241111310200, 231111110800); Key project at central government level: The ability establishment of sustainable use for valuable Chinese medicine resources (2060302); Major Science and Technology Projects in Henan Province (221100310400); Henan Academy of Agricultural Sciences Emerging Discipline Development Project (2024XK01); Henan Academy of Agricultural Sciences Independent Innovation Special Fund (2024ZC040); Henan Academy of Agricultural Sciences Outstanding Youth Science and Technology Fund (2024YQ15, 2024YQ16); Henan Province Science and Technology Research Projects (232102110198, 232102110243, 232102110262, 242102110248, 242102110260); (Provincial Key Laboratory of Conservation and Utilization of Traditional Chinese Medicine Resources, Institute of Chinese Herbal Medicines, Henan Academy of Agricultural Sciences, Zhengzhou, Henan, China). Conflict of Interest Disclosure The authors affirm that this research was conducted without any commercial or financial relationships that could be construed as a potential conflict of interest.
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