Medicinal Plant Research 2024, Vol.14, No.1, 57-70 http://hortherbpublisher.com/index.php/mpr 57 Feature Review Open Access Clinical Applications and Efficacy of Achyranthes bidentata in Bone and Joint Disorders Wei Dong, Yongliang Yu, Lanjie Xu, Hongqi Yang, Qing Yang, Huizhen Liang Institute of Chinese Herbal Medicine, He'nan Academy of Agricultural Sciences, Zhengzhou, 450002, Henan, China Corresponding email: lhzh66666@163.com Medicinal Plant Research, 2024, Vol.14, No.1 doi: 10.5376/mpr.2024.14.0005 Received: 10 Jan., 2024 Accepted: 16 Feb., 2024 Published: 28 Feb., 2024 Copyright © 2024 Dong et al., This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Preferred citation for this article: Dong W., Yu Y.L., Xu L.J., Yang H.Q., Yang Q., and Liang H.Z., 2024, Clinical applications and efficacy of Achyranthes bidentata in bone and joint disorders, Medicinal Plant Research, 14(1): 57-70 (doi: 10.5376/mpr.2024.14.0005) Abstract Achyranthes bidentata Bl., a traditional Chinese medicine, is widely used for its therapeutic effects on bone and joint disorders. This study introduces the botanical characteristics and pharmacologically active components of Achyranthes bidentata, and it thoroughly explores the pharmacological actions of these components, such as anti-inflammatory, antioxidant, immunomodulatory, and bone and cartilage protective functions. The study analyzes the application of Achyranthes bidentatain clinical trials, particularly its efficacy and safety in the treatment of diseases such as osteoarthritis, rheumatoid arthritis, and osteoporosis. By comparing the effectiveness of Achyranthes bidentata with conventional treatments and its synergistic effects in multi-drug formulations, the potential of Achyranthes bidentata as an alternative or complementary therapy is evaluated. Finally, the study points out the current research deficiencies and future research directions. This study aims to deeply evaluate the clinical applications and efficacy of Achyranthes bidentatain the treatment of bone and joint disorders, to promote further application and research of this herb. Keywords Achyranthes bidentata; Bone and joint disorders; Pharmacological properties; Clinical trials; Efficacy evaluation 1 Introduction Bone and joint disorders, including osteoporosis and osteoarthritis, are prevalent conditions that significantly impact the quality of life, particularly among the elderly population. Osteoporosis is characterized by reduced bone mass and deterioration of bone tissue, leading to increased fracture risk. Osteoarthritis, on the other hand, involves the degeneration of joint cartilage and underlying bone, causing pain and stiffness. These conditions not only impose a substantial burden on healthcare systems but also affect the mobility and independence of individuals (Zhang et al., 2018; Zhang et al., 2019). Achyranthes bidentata Bl., a traditional Chinese medicinal herb, has been extensively used for its therapeutic properties in treating bone and joint disorders. Historically, it has been prescribed to strengthen bones and alleviate symptoms associated with osteoporosis and osteoarthritis. The root of Achyranthes bidentata is particularly valued for its anti-inflammatory, osteoprotective, and chondroprotective effects (Lin et al., 2019; Chen et al., 2020). Recent studies have demonstrated that various extracts and compounds derived from Achyranthes bidentata, such as polysaccharides and steroid-enriched fractions, exhibit significant efficacy in preventing bone loss and promoting bone formation (Yan et al., 2019; Zhang et al., 2020; Yin et al., 2022). This study comprehensively analyzed the pharmacological effects of Achyranthes bidentata on bone and joint health and delved into the specific mechanisms behind its therapeutic efficacy. It evaluated the clinical evidence supporting the use of Achyranthes bidentata in managing osteoporosis and osteoarthritis and explored potential areas for future research and clinical applications. Additionally, the study discussed the effectiveness of Achyranthes bidentata at different treatment stages, its target populations, and possible side effects, providing a systematic and comprehensive perspective. By integrating various research findings, we aim to thoroughly understand the potential of Achyranthes bidentata as an alternative or complementary treatment for bone and joint diseases, thereby offering a scientific basis for further research and practical application.
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