Medicinal Plant Research 2024, Vol.14, No.1, 45-56 http://hortherbpublisher.com/index.php/mpr 53 et al., 2023) indicated that Chrysanthemum morifoliumextract improved sleep quality in rodent models without any reported toxicity, further supporting its safety in traditional medicinal use. 7.2 Safety in traditional use Chrysanthemum morifoliumhas a long history of use in traditional medicine, particularly in East Asia, where it is commonly consumed as tea or used in herbal remedies. The traditional use of Chrysanthemum morifolium is generally considered safe, as evidenced by its widespread consumption over centuries. The study by (Li et al., 2019b) highlighted the anti-inflammatory and antioxidant properties of Chrysanthemum morifoliumteas, which are consumed daily by many people. This long-term traditional use without significant adverse effects supports the safety of Chrysanthemum morifoliumin its conventional forms. 7.3 Regulatory status and quality control The regulatory status of Chrysanthemum morifoliumvaries by region, but it is generally recognized as safe when used in food and traditional medicine. Quality control measures are crucial to ensure the safety and efficacy of Chrysanthemum morifolium products. The study by (Chen et al., 2020) utilized liquid chromatography mass spectrometry to identify and quantify the chemical compounds in various cultivars of Chrysanthemum morifolium, providing a basis for standardizing and ensuring the quality of these products. Additionally, the study by (Youssef et al., 2020) compared the chemical composition and biological activities of essential oils fromChrysanthemum morifolium, emphasizing the importance of rigorous quality control to maintain the safety and therapeutic potential of these products. In conclusion, the available studies indicate that Chrysanthemum morifoliumis generally safe for both acute and chronic use, supported by its long history in traditional medicine and current regulatory standards. However, ongoing research and stringent quality control are essential to ensure its continued safety and efficacy. 8 Future Directions and Research Opportunities 8.1 Unexplored bioactivities Despite the extensive research on the chemical composition and known bioactivities of Chrysanthemum morifolium, there remain numerous unexplored bioactivities that warrant further investigation. For instance, while the antiviral, antimicrobial, and antioxidant properties have been well-documented (Youssef et al., 2020), other potential bioactivities such as anti-inflammatory, anti-cancer, and neuroprotective effects have not been thoroughly examined. Future studies should focus on these areas to fully elucidate the therapeutic potential of C. morifolium. 8.2 Advanced analytical techniques The application of advanced analytical techniques can significantly enhance our understanding of the chemical characteristics of C. morifolium. Techniques such as high-resolution mass spectrometry, nuclear magnetic resonance (NMR) spectroscopy, and advanced chromatographic methods can provide more detailed and accurate profiles of the bioactive compounds present in C. morifolium(Chen et al., 2020). These techniques can also help in identifying novel compounds that may contribute to the plant's bioactivity. 8.3 Integrative approaches in therapy Integrative approaches that combine the use of C. morifolium with other therapeutic modalities could offer synergistic benefits. For example, combining C. morifoliumextracts with conventional antimicrobial agents may enhance their efficacy and reduce the risk of resistance development. Additionally, the incorporation of C. morifoliumin dietary supplements and functional foods could provide a holistic approach to health and wellness, leveraging its rich content of flavonoids and caffeoylquinic acids (Chen et al., 2020). 8.4 Sustainable cultivation and harvesting Sustainable cultivation and harvesting practices are crucial for ensuring the long-term availability of C. morifolium. Research should focus on developing eco-friendly agricultural practices that minimize environmental impact while maximizing yield and quality. This includes exploring organic farming methods, optimizing harvest
RkJQdWJsaXNoZXIy MjQ4ODYzNA==