Medicinal Plant Research 2024, Vol.14, No.1, 11-30 http://hortherbpublisher.com/index.php/mpr 16 Figure 1 Effects of MH on the (A) translocation, (B) cytosol, nuclear protein expression, phosphorylation of NF-κB p65, and phosphorylation and degradation of IκBα (Adopted from Park et al., 2022) Image caption: figure demonstrates the inhibitory effect of MH on the NF-κB signaling pathway in LPS-induced BV2 cells. Figure 1A shows that LPS stimulation significantly increased the fluorescence intensity of NF-κB p65 in the nucleus, and this effect was reduced in a dose-dependent manner in the presence of MH, indicating that MH inhibited the nuclear translocation of NF-κB p65. Figure 1B shows that LPS treatment increased the phosphorylation and degradation of IκBα, activating NF-κB p65, while MH pretreatment reduced these changes. This further suggests that MH alleviates neuroinflammatory responses by inhibiting the degradation of IκBα and the phosphorylation of NF-κB p65 (Adapted from Park et al., 2022)
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