Journal of Tea Science Research, 2024, Vol.14, No.3, 134-147 http://hortherbpublisher.com/index.php/jtsr 134 Systematic Review Open Access Integrative Omics: Metabolomics and Transcriptomics in Tea Research YuexinLi 1, YingZhu3, Yichen Zhao2 1 Guizhou Tea Research Institute / Plant Conservation & Breeding Technology Center, Guizhou Academy of Agricultural Sciences, Guiyang, 550006, Guizhou, China 2 Key Laboratory of Plant Resources Conservation and Germplasm Innovation in Mountainous Region (Ministry of Education), College of Tea Sciences, Guizhou University, Guiyang, 550025, Guizhou, China 3 Guizhou Plant Conservation & Breeding Technology Center and Guizhou Key Laboratory of Agricultural Biotechnology, Institute of Biotechnology, Guizhou Academy of Agricultural Sciences, Guiyang, 550006, Guizhou, China Corresponding author: yczhao@gzu.edu.cn Journal of Tea Science Research, 2024, Vol.14, No.3 doi: 10.5376/jtsr.2024.14.0013 Received: 20 Mar., 2024 Accepted: 25 Apr., 2024 Published: 12 May, 2024 Copyright © 2024 Li et al., This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Preferred citation for this article: Li Y.X., Zhu Y., and Zhao Y.C., 2024, Integrative omics: metabolomics and transcriptomics in tea research, Journal of Tea Science Research, 14(3): 134-147 (doi: 10.5376/jtsr.2024.14.0013) Abstract This study explores the integrated application of metabolomics and transcriptomics in tea research, providing a comprehensive overview of how these omics technologies advance the understanding of tea plant biology, development, and stress responses. Through an analysis of extensive research, the study highlights significant discoveries in the biosynthesis of key metabolites such as catechins and theaflavins, which are crucial for the quality and health benefits of tea. The integration of metabolomics and transcriptomics offers new perspectives on revealing stress response genes and metabolic pathways, contributing to the development of stress-resistant tea plant varieties. This study underscores the innovative potential of omics technologies in tea research and development, providing unique insights and strategies for future research directions and practical applications in the field. Keywords Tea (Camellia sinensis); Metabolomics; Transcriptomics; Integrative omics; Gene-metabolite networks 1 Introduction Omics technologies have revolutionized modern plant science by enabling comprehensive analyses of biological systems. These technologies, encompassing genomics, proteomics, metabolomics, and transcriptomics, allow researchers to delve deeply into the molecular mechanisms governing plant development, physiology, and interactions with the environment (Ran et al., 2019). The advent of omics technologies has significantly advanced our understanding of plant biology. By providing high-throughput data on various biomolecules, these technologies facilitate the identification of key metabolic pathways, regulatory networks, and gene functions. This holistic approach is particularly valuable in plant science, where the complexity of biological processes necessitates a comprehensive and integrative analytical framework (Patterson et al., 2019). Omics technologies are indispensable for crop improvement, stress resistance studies, and the development of sustainable agricultural practices (Yang et al., 2021). Metabolomics and transcriptomics are two pivotal branches of omics technologies. Metabolomics involves the large-scale study of metabolites, the small molecules involved in metabolism, providing insights into the biochemical activities within a plant. Transcriptomics, on the other hand, focuses on the transcriptome--the complete set of RNA transcripts produced by the genome under specific circumstances. Together, these technologies offer a detailed picture of the functional state of an organism, linking gene expression to metabolic outcomes (Crandall et al., 2020). This study integrates metabolomics and transcriptomics data to enhance the understanding of the biology of the tea plant (Camellia sinensis). By synthesizing findings from existing research, it reveals metabolites and genes closely associated with the physiological processes and growth development of the tea plant. The study not only elucidates the metabolic pathways and regulatory mechanisms that play a decisive role in tea quality and stress
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