Journal of Tea Science Research, 2024, Vol.14, No.2, 102-111 http://hortherbpublisher.com/index.php/jtsr 110 polyphenols, as well as their interactions with gut microbiota, will be important for developing effective dietary recommendations and therapeutic applications. In conclusion, tea polyphenols hold great promise as natural antioxidants with significant potential in chronic disease prevention. Continued research and collaboration between the tea industry and public health sectors will be essential to fully harness their benefits and address the challenges in this field. Acknowledgments The authors extend sincere thanks to two anonymous peer reviewers for their invaluable feedback on the manuscript of this study. Conflict of Interest Disclosure The authors affirm that this research was conducted without any commercial or financial relationships that could be construed as a potential conflict of interest. References Baeza G., Sarriá B., Bravo L., and Mateos R., 2018, Polyphenol content, in vitro bioaccessibility and antioxidant capacity of widely consumed beverages, Journal of the Science of Food and Agriculture, 98(4): 1397-1406. https://doi.org/10.1002/jsfa.8607 Cicero A.F., and Colletti A., 2018, Polyphenols effect on circulating lipids and lipoproteins: from biochemistry to clinical evidence, Current Pharmaceutical Design, 24(2): 178-190. https://doi.org/10.2174/1381612824666171128110408 Diao J.X., Ou J.Y., Dai H., Li H.Y., Huang W., Hua H.Y., Xie T., Wang M., and Yang Y.G., 2019, Antioxidant and antiapoptotic polyphenols from green tea extract ameliorate CCl₄-induced acute liver injury in mice, Chinese Journal of Integrative Medicine, 26(10): 736-744. https://doi.org/10.1007/s11655-019-3043-5 Di Meo F., Valentino A., Petillo O., Peluso G., Filosa S., and Crispi S., 2020, Bioactive polyphenols and neuromodulation: molecular mechanisms in neurodegeneration, International Journal of Molecular Sciences, 21(7): 2564. https://doi.org/10.3390/ijms21072564 Giglio R.V., Patti A.M., Cicero A.F., Lippi G., Rizzo M., Toth P.P., and Banach M., 2018, Polyphenols: potential use in the prevention and treatment of cardiovascular diseases, Current Pharmaceutical Design, 24(2): 239-258. https://doi.org/10.2174/1381612824666180130112652 Hong M., Yu J., Wang X., Liu Y., Zhan S., Wu Z., and Zhang X., 2022, Tea polyphenols as prospective natural attenuators of brain aging, Nutrients, 14(15): 3012. https://doi.org/10.3390/nu14153012 Li Q., Qiu Z., Wang Y., Guo C., Cai X., Zhang Y., Liu L., Xue H., and Tang J., 2021, Tea polyphenols alleviate hydrogen peroxide-induced oxidative stress damage through the Mst/Nrf2 axis and the Keap1/Nrf2/HO-1 pathway in murine RAW264.7 cells, Experimental and Therapeutic Medicine, 22. https://doi.org/10.3892/etm.2021.10908 Liu B., Ma R., Zhang J., Sun P., Yi R., and Zhao X., 2019, Preventive effect of small-leaved Kuding tea (Ligustrum robustum(Roxb.) Bl.) polyphenols on D-galactose-induced oxidative stress and aging in mice, Evidence-Based Complementary and Alternative Medicine, 2019(1): 3152324. https://doi.org/10.1155/2019/3152324 Ma Y., Ma X., An Y., Sun Y., Dou W., Li M., Bao H., and Zhang C., 2022, Green tea polyphenols alleviate hydrogen peroxide-induced oxidative stress, inflammation, and apoptosis in bovine mammary epithelial cells by activating ERK1/2–NFE2L2–HMOX1 pathways, Frontiers in Veterinary Science, 8: 804241. https://doi.org/10.3389/fvets.2021.804241 Mokra D., Adamcakova J., and Mokry J., 2022a, Green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG): a time for a new player in the treatment of respiratory diseases?, Antioxidants, 11(8): 1566. https://doi.org/10.3390/antiox11081566 Mokra D., Joskova M., and Mokry J., 2022b, Therapeutic effects of green tea polyphenol (‒)-epigallocatechin-3-gallate (EGCG) in relation to molecular pathways controlling inflammation, oxidative stress, and apoptosis, International Journal of Molecular Sciences, 24(1): 340. https://doi.org/10.3390/ijms24010340 Olcha P., Winiarska-Mieczan A., Kwiecień M., Nowakowski Ł., Miturski A., Semczuk A., Kiczorowska B., and Gałczyński K., 2022, Antioxidative, anti-inflammatory, anti-obesogenic, and antidiabetic properties of tea polyphenols—the positive impact of regular tea consumption as an element of prophylaxis and pharmacotherapy support in endometrial cancer, International Journal of Molecular Sciences, 23(12): 6703. https://doi.org/10.3390/ijms23126703 Ru Q., Xiong Q., Tian X., Chen L., Zhou M., Li Y., and Li C., 2019, Tea polyphenols attenuate methamphetamine-induced neuronal damage in PC12 cells by alleviating oxidative stress and promoting DNA repair, Frontiers in Physiology, 10: 1450. https://doi.org/10.3389/fphys.2019.01450
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