Journal of Tea Science Research, 2024, Vol.14, No.1, 52-56 http://hortherbpublisher.com/index.php/jtsr 52 Scientific Commentary OpenAcces From Tea Leaves to Skincare: New Perspectives on Anti-Aging Research with Assam Tea Extract Henry Smith Journal of Tea Science Research, HortHerb Publisher, Richmond, BC, V7A 4Z5, Canada Corresponding email: henry.smith@sophiapublisher.com Journal of Tea Science Research, 2024, Vol.14, No.1 doi: 10.5376/jtsr.2024.14.0005 Received: 27 Jan., 2024 Accepted: 20 Feb., 2024 Published: 29 Feb., 2024 Copyright © 2024 Smith, This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Preferred citation for this article: Smith H., 2024, From tea leaves to skincare: new perspectives on anti-aging research with Assam tea extract, Journal of Tea Science Research, 14(1): 52-56 (doi: 10.5376/jtsr.2024.14.0005) The paper titled "Recent insights into catechins-rich Assam tea extract for photoaging and senescent ageing" was published on January 26, 2024, in the open-access journal Scientific Reports, under the Nature Publishing Group. The authors, Mayuree Kanlayavattanakul, Mattaka Khongkow, Wannita Klinngam, Puxvadee Chaikul, Nattaya Lourith, and Piyaporn Chueamchaitrakun, are from Mae Fah Luang University and the National Nanotechnology Center (NANOTEC) in Thailand. This study systematically evaluated the antioxidant, anti-photoaging, and anti-aging activities of Assam tea extract (ATE) through in vitro and ex vivo experiments, confirming ATE's potential as a novel anti-aging product. The research showed that ATE not only exhibits excellent antioxidant activity but also significantly reduces UV-induced inflammation and matrix metalloproteinase (MMP) activity. These findings suggest that ATE can be applied as an innovative anti-aging agent in cosmetics and health promotion products. 1 Interpretation of Experimental Data The study systematically evaluated the antioxidant, anti-photoaging, and anti-aging activities of Assam tea extract (ATE) through a series of in vitro and ex vivo experiments. Using HPLC analysis and various antioxidant assays (ABTS, DPPH, and FRAP), the study determined the content of the main active components in ATE and assessed its antioxidant capacity. Additionally, the chemical stability of ATE under different storage conditions was evaluated. Figure 1A shows Assam tea leaves and their processed powder and extract, with the extract appearing light brown. Figure 1B lists the main catechins and caffeine detected in the study, quantified using a standardized HPLC method. The results indicate that epigallocatechin gallate (EGCG) is the predominant catechin in the extract (p < 0.001), while gallocatechin gallate (GCG) is the least abundant (Figure 1C). Additionally, a high level of caffeine was detected in the extract (10.90 ± 0.36 g/100 g extract). These results demonstrate that Assam tea extract is rich in various health-beneficial catechins, particularly EGCG, which has significant health-promoting potential. Figure 4 demonstrates the safety of Assam tea extract (ATE) in a human ex vivo skin model and its effects on the expression of IL-6, MMP-1, hyaluronic acid, and PIP. Figure 4A indicates that ATE is non-cytotoxic to the skin at concentrations ranging from 0.1 to 2 mg/mL. Figure 4B shows that ATE significantly inhibits the expression of IL-6 and MMP-1 in senescent cells, with effects comparable to or stronger than EGCG (p<0.05). Figure 4C indicates that ATE significantly promotes the production of hyaluronic acid but is less effective than EGCG in promoting PIP expression. These results suggest that ATE can effectively inhibit inflammation and collagen degradation while promoting the production of skin moisturizing components at non-cytotoxic concentrations, indicating its good anti-aging potential.
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