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Intl. J. of Molecular Zoology, 2011, Vol.1, No.2, 4
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Figure 3 Polyphyletic tree of
Scandentia
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As an Experimental Animals
In view of the closely relationship between treeshrews
and primates, and treesthew’s unique characteristics
suitable for laboratory animal, such as relatively small
body mass, high brain-to-body mass ratio, short
reproductive cycle and life span, treeshrews have been
proposed to be used as an experimental animal
alternative to primates. For the past decades,
treeshrews as an alternative animal model has been
widely applied in biomedical research and medicine
safety testing (Cao et al., 2003).
So far, many progresses have been archive on establishing
treeshrews as an animal modle for medical research.
Two human virus infection models, hepatitis C virus
(
HCV) and hepatitis B virus (HBV), have been
established (Yan et al., 1996, Zhao et al., 2002,);
myopia research model (Norton et al., 2006), social
stress and depression research model (Fuchs, 2005;
Kampen et al., 2002) and the models of aging and learning
behaviors (Yamashita, et al., 2012; Bartolomucci et
al., 2002) have been reported as well. Obviously,
with the advances in modern molecular biology,
especially in the development of next-generation
genome sequencing technology, the deciphering of the
genetic code of treeshrews will make treeshrews
become an important alternative for medical research
and drug trials alternative to nonhuman primates.
References
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