Basic HTML Version
分子植物育种
(
网络版
), 2012
年
,
第
10
卷
,
第
1097
-
1103
页
Fenzi Zhiwu Yuzhong (Online), 2012, Vol.10, 1097
-
1103
http://mpb.5th.sophiapublisher.com
1102
UDPGA (UDP
-葡萄糖醛酸
, UDP-glucuronic acid)
合
成黄酮葡糖苷酸
(
图
2)
。由于黄酮葡糖苷酸在唇形目
植物，因此植物
F7GAT
的研究主要集中于唇形目
植物。最早得到纯化的
F7GAT
是黄芩的
Sb
UBGAT
， 其
cDNA
也 得 到 了 克 隆
(GenBank:
AB042277.1)
。最新研究克隆了唇形目光紫黄芩
(
Scutellaria laeteviolacea
)
、紫苏
(
P. frutescens
)
、金鱼
草
(
Antirrhinum majus
)
和芝麻
(
Sesamum indicum
)
等
的
F7GAT
基因
(Noguchi, et al., 2009)
。这些植物
(
包
括黄芩
) F7GAT
的底物特异性，即其糖基供体是
UDPGA
而不是
UDP
-葡萄糖，是因为单个氨基酸残
基
(Arg
取代
Trp)
改变所引起的，这是黄酮葡糖苷酸
形成的分子基础。但是，除唇形目外，其他植物的
F7GAT
尚没有研究，其他植物
F7GAT
的底物特异
性形成的分子机理是否也是如此需要深入的研究。
作者贡献
刘毅完成文献检索及论文初稿的写作；杨生超是本项
目的负责人；张广辉，陈军文指导论文写作与修改。
致谢
本研究由国家自然科学基金
(8130499)
资助。
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