CMB-2015v5n5 - page 8

Computational Molecular Biology 2015, Vol. 5, No. 5, 1-9
http://cmb.biopublisher.ca
5
The MMP1 and MMP7 genes is mainly involved in
colon tissues by regulating immune response, K-ras
are an oncogene it helps to transcriptional regulation
by inhibiting p53 gene expression with MDM2
receptor to cause colon cancer (Figure: 4).
C. Ovarian cancer
The ovarian cancer studies has 6 samples of which 3
samples is p53 targeted TOV112D cells untreated and
other 3 samples P53 targeted NSC319726 cells data.
There are total of 54675 genes of which 1566 genes is
signific antly assoc iated differential express ion in
ovarian cancer. There are 810 genes is upregulated
within ovarian tissues of which p53 associated with
cancer and control tissues, 756 genes dow regulated
based on significant test (Figure: 5). Using SVM
classification methods we have classified both significant
genes in both the datasets shows only 309 genes is
probabilistic expression with ovarian cancer. 175 genes
is p53 mutation association with TOV112D and
NSC319726 cells, these genes is targeted for ovarian
cancer therapeutic properties and is used for best
biomarkers (table:5,6). The significant genes associated
Table 2 Significant genes in breast cancer that is involved in gene-gene interaction
Gene Ranking Gene ID Mean Diff Express UP/Down Redundant
1 241763_s_at 1.92 UP FALSE
2 1558048_x_at 1.4645 UP TRUE
3 241762_at 1.4404 UP TRUE
4 225803_at 1.352 UP TRUE
5 211906_s_at 1.3315 UP TRUE
6 202270_at 1.3159 UP TRUE
7 231577_s_at 1.2727 UP TRUE
8 205440_s_at 1.2299 UP TRUE
9 214702_at 1.3266 UP TRUE
10 202269_x_at 1.1202 UP TRUE
11 204259_at 1.2022 UP TRUE
12 227404_s_at 1.1577 UP TRUE
13 209720_s_at 1.1845 UP TRUE
14 229800_at 1.0121 UP TRUE
15 225328_at 1.0491 UP TRUE
16 218162_at 1.0409 UP TRUE
17 238623_at 1.0733 UP TRUE
18 230493_at -0.8728 DOWN FALSE
19 209719_x_at 0.966 UP TRUE
20 210413_x_at 0.9609 UP TRUE
21 222940_at 0.9466 UP TRUE
22 201694_s_at 0.9359 UP TRUE
23 211896_s_at 0.8786 UP TRUE
24 217997_at -0.9454 DOWN TRUE
25 205422_s_at 1.0944 UP TRUE
26 219553_at -0.8652 DOWN TRUE
27 203854_at 0.8962 UP TRUE
28 224549_x_at 0.8446 UP TRUE
29 209335_at 0.8693 UP TRUE
30 232573_at 0.8754 UP TRUE