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International Journal of Molecular Veterinary Research
2013, Vol.3, No.6, 23
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27
carcinogens (Levine, 1975). Teratogenic effects of
DMSO have been reported in birds and mammals
(Caujolle et al., 1967). Chronic thermal, chemical
exposure of DMSO solvent and higher levels of
chemical contaminants with severe electrical burns
causes the invasive squamous cell carcinoma of the
upper extremities in human beings (Chang, 2011). It
requires reduction in exposure to DMSO and
reduction in toxic effects before the use of DMSO in
stem cell cryopreservation (Windrum et al., 2005).
4 Conclusion
Dimethyl sulfoxide’s effectiveness as a penetrant,
penetrant carrier, cryoprotectant, radioprotectent,
antiischemic, anti-inflammatory and analgesic agent is
well established. Side effects of DMSO such as mast
cell degranulation, diuresis and volume depletion may
exacerbate patient’s preexisting problems and should
be considered before the treatment is initiated.
Dimethyl sulfoxide will have a role in veterinary
patients for the treatment of sprain, bursitis, proud
flesh, synovitis, postoperative swelling, otitis,
pruritis, burn, ulcers and pain management if
suitable preparation is introduced commercially as a
drug in India.
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